Iodine promoted dual oxidative C(sp3)-H amination of 2-methyl-3-arylquinazolin-4(3H)-ones: a facile route to 1,4-diarylimidazo[1,5-a]quinazolin-5(4H)-ones

被引：14

作者：

Donthiboina, Kavitha ^{[1
,2
]}

Namballa, Hari Krishna ^{[1
,2
]}

Shaik, Siddiq Pasha ^{[2
]}

Nanubolu, Jagadeesh Babu ^{[3
]}

Shankaraiah, Nagula ^{[1
]}

Kamal, Ahmed ^{[1
,2
]}

机构：

[1] NIPER, Dept Med Chem, Hyderabad 500037, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Dept Med Chem & Biotechnol, Hyderabad 500007, Andhra Pradesh, India

[3] Indian Inst Chem Technol, CSIR, Lab Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 10期

关键词：

C-H BONDS; METAL-FREE CONDITIONS; ONE-POT SYNTHESIS; PRACTICAL SYNTHESIS; EFFICIENT SYNTHESIS; ACRIDONE ALKALOIDS; CYCLIZATION; FUNCTIONALIZATION; QUINAZOLINES; DERIVATIVES;

D O I：

10.1039/c7ob02677c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iodine promoted tandem oxidative condensation of benzylamines and 2-methylquinazolin-4-(3H)-ones was developed to yield imidazo[1,5-a] quinazolin-5(4H)-ones via dual C(sp(3))-H amination under metal free conditions in a greener way using molecular oxygen as a terminal oxidant. This tandem transformation provides an efficient approach to construct various functionalized imidazo[1,5-a] quinazolin-5(4H)-ones in a straightforward manner via a sequential amination-oxidation-annulation-aromatisation.

引用

页码：1720 / 1727

页数：8

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