Access to Different Nanostructures via Self-Assembly of Thiourea-Containing PEGylated Amphiphiles

被引：12
|
作者：
Venkataraman, Shrinivas [1 ]
Chowdhury, Zarir Ashraf [2 ]
Lee, Ashlynn L. [1 ]
Tong, Yen Wah [2 ]
Akiba, Isamu [3 ]
Yang, Yi Yan [1 ]
机构：
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119077, Singapore
[3] Univ Kitakyushu, Dept Chem, Kitakyushu, Fukuoka 8080135, Japan
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2013年 / 34卷 / 08期
关键词：
amphiphilic block copolymer; morphology; nanostructures; self-assembly; small-angle X-ray scattering; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; UNILAMELLAR VESICLES; BUILDING-BLOCKS; DOUBLE-BONDS; SHAPE; WATER; GELATION; UREA; NANOPARTICLES;
D O I：
10.1002/marc.201200751
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Readily water-soluble PEGylated amphiphiles containing bis-thiourea-based molecular recognition units at the interface of hydrophobic and hydrophilic blocks are developed. Self-assembly of these amphiphiles is found to be dependent on the exact chemical composition of the hydrophobic component. Elongated, spherical, and disk-like micelles are formed with the change in hydrophobic group from stearyl (2A), oleyl (2B), and dodecanol (2C), respectively. The length of the rod-like elongated micelles formed by 2A could be tuned by thermal treatment as well. Synthesis and detailed structural characterization of these amphiphiles by TEM, DSC, synchrotron SAXS techniques are reported. Organic solvent-free direct aqueous encapsulation of doxorubicin, an anticancer drug into these nanostructures is demonstrated.
引用
收藏
页码：652 / 658
页数：7
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