Access to Different Nanostructures via Self-Assembly of Thiourea-Containing PEGylated Amphiphiles

被引：12

作者：

Venkataraman, Shrinivas ^{[1
]}

Chowdhury, Zarir Ashraf ^{[2
]}

Lee, Ashlynn L. ^{[1
]}

Tong, Yen Wah ^{[2
]}

Akiba, Isamu ^{[3
]}

Yang, Yi Yan ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119077, Singapore

[3] Univ Kitakyushu, Dept Chem, Kitakyushu, Fukuoka 8080135, Japan

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2013年 / 34卷 / 08期

关键词：

amphiphilic block copolymer; morphology; nanostructures; self-assembly; small-angle X-ray scattering; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; UNILAMELLAR VESICLES; BUILDING-BLOCKS; DOUBLE-BONDS; SHAPE; WATER; GELATION; UREA; NANOPARTICLES;

D O I：

10.1002/marc.201200751

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Readily water-soluble PEGylated amphiphiles containing bis-thiourea-based molecular recognition units at the interface of hydrophobic and hydrophilic blocks are developed. Self-assembly of these amphiphiles is found to be dependent on the exact chemical composition of the hydrophobic component. Elongated, spherical, and disk-like micelles are formed with the change in hydrophobic group from stearyl (2A), oleyl (2B), and dodecanol (2C), respectively. The length of the rod-like elongated micelles formed by 2A could be tuned by thermal treatment as well. Synthesis and detailed structural characterization of these amphiphiles by TEM, DSC, synchrotron SAXS techniques are reported. Organic solvent-free direct aqueous encapsulation of doxorubicin, an anticancer drug into these nanostructures is demonstrated.

引用

页码：652 / 658

页数：7

共 50 条

[31] Enzymatic Self-Assembly of Nanostructures for Theranostics
Chen, Yue
Liang, Gaolin
THERANOSTICS, 2012, 2 (02): : 139 - 147
[32] Self-Assembly of Polyoxometalate Clusters into Nanostructures with Different Dimensions
Zhao, Yali
Wang, Ziru
Ni, Jun
He, Peilei
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2024, 27 (21)
[33] Aqueous self-assembly of chromophore-conjugated amphiphiles
Molla, Mijanur Rahaman
Ghosh, Suhrit
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 16 (48) : 26672 - 26683
[34] Chiral plasmonic nanostructures via DNA self-assembly
Wang, Meng
Dong, Jinyi
Wang, Qiangbin
CHINESE SCIENCE BULLETIN-CHINESE, 2019, 64 (10): : 1001 - 1007
[35] Synthesis of ß-Cyclodextrin Containing Copolymer via "Click" Chemistry and Its Self-Assembly in the Presence of Guest Compounds
Zhang, Jianxiang
Ellsworth, Kristin
Ma, Peter X.
MACROMOLECULAR RAPID COMMUNICATIONS, 2012, 33 (08) : 664 - 671
[36] DNA-organic molecular amphiphiles: Synthesis, self-assembly, and hierarchical aggregates
Zhao, Zhiyong
Dong, Yuanchen
Duan, Zongze
Jin, Dou
Yuan, Wei
Liu, Dongsheng
AGGREGATE, 2021, 2 (04):
[37] Synthesis, emulsification and self-assembly properties of sugar-containing semifluorinated amphiphiles
Razgulin, Andrew V.
Mecozzi, Sandro
CARBOHYDRATE RESEARCH, 2015, 406 : 10 - 18
[38] Unusual, photo-induced self-assembly of azobenzene-containing amphiphiles
Li, Zhen
Wang, Pan
Liu, Bing
Wang, Yefei
Zhang, Jun
Yan, Youguo
Ma, Yunyun
SOFT MATTER, 2014, 10 (43) : 8758 - 8764
[39] Spacer effect on nanostructures and self-assembly in organogels via some bolaform cholesteryl imide derivatives with different spacers
Jiao, Tifeng
Gao, Fengqing
Zhang, Qingrui
Zhou, Jingxin
Gao, Faming
NANOSCALE RESEARCH LETTERS, 2013, 8 : 1 - 8
[40] Spacer effect on nanostructures and self-assembly in organogels via some bolaform cholesteryl imide derivatives with different spacers
Tifeng Jiao
Fengqing Gao
Qingrui Zhang
Jingxin Zhou
Faming Gao
Nanoscale Research Letters, 8

← 1 2 3 4 5 →