Access to Different Nanostructures via Self-Assembly of Thiourea-Containing PEGylated Amphiphiles

被引：12

作者：

Venkataraman, Shrinivas ^{[1
]}

Chowdhury, Zarir Ashraf ^{[2
]}

Lee, Ashlynn L. ^{[1
]}

Tong, Yen Wah ^{[2
]}

Akiba, Isamu ^{[3
]}

Yang, Yi Yan ^{[1
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119077, Singapore

[3] Univ Kitakyushu, Dept Chem, Kitakyushu, Fukuoka 8080135, Japan

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2013年 / 34卷 / 08期

关键词：

amphiphilic block copolymer; morphology; nanostructures; self-assembly; small-angle X-ray scattering; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; UNILAMELLAR VESICLES; BUILDING-BLOCKS; DOUBLE-BONDS; SHAPE; WATER; GELATION; UREA; NANOPARTICLES;

D O I：

10.1002/marc.201200751

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Readily water-soluble PEGylated amphiphiles containing bis-thiourea-based molecular recognition units at the interface of hydrophobic and hydrophilic blocks are developed. Self-assembly of these amphiphiles is found to be dependent on the exact chemical composition of the hydrophobic component. Elongated, spherical, and disk-like micelles are formed with the change in hydrophobic group from stearyl (2A), oleyl (2B), and dodecanol (2C), respectively. The length of the rod-like elongated micelles formed by 2A could be tuned by thermal treatment as well. Synthesis and detailed structural characterization of these amphiphiles by TEM, DSC, synchrotron SAXS techniques are reported. Organic solvent-free direct aqueous encapsulation of doxorubicin, an anticancer drug into these nanostructures is demonstrated.

引用

页码：652 / 658

页数：7

共 43 条

[1] Functional Supramolecular Polymers [J].

Aida, T. ;

Meijer, E. W. ;

Stupp, S. I. .

SCIENCE, 2012, 335 (6070) :813-817

[2] Molecular recognition in bisurea thermoplastic elastomers studied with pyrene-based fluorescent probes and atomic force microscopy [J].

Botterhuis, Nicole E. ;

Karthikeyan, S. ;

Veldman, Dirk ;

Meskers, Stefan C. J. ;

Sijbesma, Rint P. .

CHEMICAL COMMUNICATIONS, 2008, (33) :3915-3917

[3] Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery [J].

Canelas, Dorian A. ;

Herlihy, Kevin P. ;

DeSimone, Joseph M. .

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2009, 1 (04) :391-404

[4] Role of target geometry in phagocytosis [J].

Champion, JA ;

Mitragotri, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :4930-4934

[5] Shape Induced Inhibition of Phagocytosis of Polymer Particles [J].

Champion, Julie A. ;

Mitragotri, Samir .

PHARMACEUTICAL RESEARCH, 2009, 26 (01) :244-249

[6] Morphological control and molecular recognition by bis-urea hydrogen bonding in micelles of amphiphilic tri-block copolymers [J].

Chebotareva, N ;

Bomans, PHH ;

Frederik, PM ;

Sommerdijk, NAJM ;

Sijbesma, RP .

CHEMICAL COMMUNICATIONS, 2005, (39) :4967-4969

[7] Self-healing and thermoreversible rubber from supramolecular assembly [J].

Cordier, Philippe ;

Tournilhac, Francois ;

Soulie-Ziakovic, Corinne ;

Leibler, Ludwik .

NATURE, 2008, 451 (7181) :977-980

[8] Crystal engineering with urea and thiourea hydrogen-bonding groups [J].

Custelcean, Radu .

CHEMICAL COMMUNICATIONS, 2008, (03) :295-307

[9] Nanoparticle therapeutics: an emerging treatment modality for cancer [J].

Davis, Mark E. ;

Chen, Zhuo ;

Shin, Dong M. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782

[10] Disk micelles from nonionic coil-coil diblock copolymers [J].

Edmonds, William F. ;

Li, Zhibo ;

Hillmyer, Marc A. ;

Lodge, Timothy P. .

MACROMOLECULES, 2006, 39 (13) :4526-4530

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