Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population

被引：122

作者：

Gardener, S. ^{[1
,2
]}

Gu, Y. ^{[3
,4
]}

Rainey-Smith, S. R. ^{[1
,2
]}

Keogh, J. B. ^{[5
,6
]}

Clifton, P. M. ^{[7
,8
,9
]}

Mathieson, S. L. ^{[2
]}

Taddei, K. ^{[1
,2
]}

Mondal, A. ^{[1
,2
]}

Ward, V. K. ^{[1
,2
]}

Scarmeas, N. ^{[3
,4
,10
]}

Barnes, M. ^{[11
]}

Ellis, K. A. ^{[12
,13
,14
]}

Head, R. ^{[11
]}

Masters, C. L. ^{[12
,15
]}

Ames, D. ^{[13
,14
]}

Macaulay, S. L. ^{[16
]}

Rowe, C. C. ^{[17
,18
]}

Szoeke, C. ^{[16
]}

Martins, R. N. ^{[1
,2
]}

机构：

[1] Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, Joondalup, WA 6027, Australia

[2] Hollywood Private Hosp, Sir James McCusker Alzheimers Dis Res Unit, Perth, WA, Australia

[3] Columbia Univ, Taub Inst Res Alzheimers Dis & Ageing Brain, New York, NY USA

[4] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

[5] Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia

[6] Univ S Australia, Sansom Inst Hlth Res, Div Hlth Sci, Adelaide, SA 5001, Australia

[7] Univ Adelaide, Dept Med, Adelaide, SA 5001, Australia

[8] Univ Adelaide, Dept Biomed Sci, Adelaide, SA, Australia

[9] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia

[10] Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

[11] CSIRO, Preventat Hlth Flagship, Adelaide, SA, Australia

[12] Univ Melbourne, Mental Hlth Res Inst, Parkville, Vic 3052, Australia

[13] Natl Ageing Res Inst, Parkville, Vic, Australia

[14] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, St Vincents Aged Psychiat Serv,St Georges Hosp, Melbourne, Vic 3010, Australia

[15] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia

[16] CSIRO, CMSE Parkville, Preventat Hlth Flagship, Parkville, Vic, Australia

[17] Austin Hlth, Dept Nucl Med, Heidelberg, Vic, Australia

[18] Austin Hlth, Ctr PET, Heidelberg, Vic, Australia

来源：

TRANSLATIONAL PSYCHIATRY | 2012年 / 2卷

基金：

英国医学研究理事会;

关键词：

AIBL; Alzheimer's disease; Australia; Mediterranean diet; MCI; MILD COGNITIVE IMPAIRMENT; OLIVE OIL; INFLAMMATION; ANTIOXIDANTS; BIOMARKERS; VEGETABLES; OXIDATION; MARKERS; CANCER; ENERGY;

D O I：

10.1038/tp.2012.91

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants. Translational Psychiatry (2012) 2, e164; doi:10.1038/tp.2012.91; published online 2 October 2012

引用

页码：e164 / e164

页数：7

共 46 条

[1] Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels [J].