Iron deficiency anemia in heart failure

被引:25
作者
Arora, Natasha P. [1 ]
Ghali, Jalal K. [2 ]
机构
[1] Wayne State Univ, Detroit Med Ctr, Detroit, MI 48201 USA
[2] Wayne State Univ, DMC Cardiovasc Inst, Detroit, MI 48201 USA
关键词
Anemia; Iron deficiency; Heart failure; Iron therapy; BLUNTED ERYTHROPOIETIN PRODUCTION; INCREASES VASCULAR SUPEROXIDE; SERUM TRANSFERRIN RECEPTOR; FERRIC GLUCONATE COMPLEX; INTRAVENOUS IRON; BLOOD-DONATION; NADPH OXIDASE; ENDOTHELIAL DYSFUNCTION; ATHEROSCLEROTIC LESIONS; MYOCARDIAL-INFARCTION;
D O I
10.1007/s10741-012-9342-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Anemia and iron deficiency are quite prevalent in patients with heart failure (HF) and may overlap. Both anemia and iron deficiency are associated with worse symptoms and adverse clinical outcomes. In the past few years, there has been an enormous interest in the subject of iron deficiency and its management in patients with HF. In this review, the etiology and relevance of iron deficiency, iron metabolism in the setting of HF, studies on iron supplementation in patients with HF and potential cardiovascular effects of subclinical iron overload are discussed.
引用
收藏
页码:485 / 501
页数:17
相关论文
共 126 条
[1]   Prospective evaluation of the association between hemoglobin concentration and quality of life in patients with heart failure [J].
Adams, Kirkwood F., Jr. ;
Pina, Ileana L. ;
Ghali, Jalal K. ;
Wagoner, Lynne E. ;
Dunlap, Stephanie H. ;
Schwartz, Todd A. ;
Stough, Wendy Gattis ;
Mehra, Mandeep R. ;
Felker, Gary Michael ;
Chiong, Jun R. ;
Patterson, James Herbert ;
Kim, John ;
Butler, Javed ;
Oren, Ron M. .
AMERICAN HEART JOURNAL, 2009, 158 (06) :965-971
[2]   Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume [J].
Adlbrecht, Christopher ;
Kommata, Spyridoula ;
Huelsmann, Martin ;
Szekeres, Thomas ;
Bieglmayer, Christian ;
Strunk, Guido ;
Karanikas, Georgios ;
Berger, Rudolf ;
Moertl, Deddo ;
Kletter, Kurt ;
Maurer, Gerald ;
Lang, Irene M. ;
Pacher, Richard .
EUROPEAN HEART JOURNAL, 2008, 29 (19) :2343-2350
[3]   Iron sucrose causes greater proteinuria than ferric gluconate in non-dialysis chronic kidney disease [J].
Agarwal, R. ;
Rizkala, A. R. ;
Kaskas, M. O. ;
Minasian, R. ;
Trout, J. R. .
KIDNEY INTERNATIONAL, 2007, 72 (05) :638-642
[4]   Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease [J].
Agarwal, R ;
Vasavada, N ;
Sachs, NG ;
Chase, S .
KIDNEY INTERNATIONAL, 2004, 65 (06) :2279-2289
[5]   Anemia and change in hemoglobin over time related to mortality and morbidity in patients with chronic heart failure results - From Val-HeFT [J].
Anand, IS ;
Kuskowski, MA ;
Rector, TS ;
Florea, VG ;
Glazer, RD ;
Hester, A ;
Chiang, YT ;
Aknay, N ;
Maggioni, AP ;
Opasich, C ;
Latini, R ;
Cohn, JN .
CIRCULATION, 2005, 112 (08) :1121-1127
[6]   Mammalian iron transport [J].
Anderson, Gregory Jon ;
Vulpe, Christopher D. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (20) :3241-3261
[7]   Medical progress: Disorders of iron metabolism [J].
Andrews, NC .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (26) :1986-1995
[8]   Hemodilution is common in patients with advanced heart failure [J].
Androne, AS ;
Katz, SD ;
Lund, L ;
LaManca, J ;
Hudaihed, A ;
Hryniewicz, K ;
Mancini, DM .
CIRCULATION, 2003, 107 (02) :226-229
[9]   The syndrome of cardiac cachexia [J].
Anker, SD ;
Sharma, R .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 85 (01) :51-66
[10]   Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency. [J].
Anker, Stefan D. ;
Comin Colet, Josep ;
Filippatos, Gerasimos ;
Willenheimer, Ronnie ;
Dickstein, Kenneth ;
Drexler, Helmut ;
Luescher, Thomas F. ;
Bart, Boris ;
Banasiak, Waldemar ;
Niegowska, Joanna ;
Kirwan, Bridget-Anne ;
Mori, Claudio ;
Rothe, Barbara von Eisenhart ;
Pocock, Stuart J. ;
Poole-Wilson, Philip A. ;
Ponikowski, Piotr .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (25) :2436-2448