Neural effects of transcranial magnetic stimulation at the single-cell level

被引：115

作者：

Romero, Maria C. ^{[1
,2
,3
]}

Davare, Marco ^{[2
,3
]}

Armendariz, Marcelo ^{[1
,3
]}

Janssen, Peter ^{[1
,3
]}

机构：

[1] Katholieke Univ Leuven, Lab Neuro & Psychofysiol, Leuven, Belgium

[2] Katholieke Univ Leuven, Onderzoeksgrp Bewegingscontrole & Neuroplasticite, Leuven, Belgium

[3] Katholieke Univ Leuven, Leuven Brain Inst, Leuven, Belgium

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

关键词：

NONINVASIVE BRAIN-STIMULATION; DORSAL PREMOTOR CORTEX; PRIMARY MOTOR CORTEX; CONCURRENT TMS-FMRI; COGNITIVE NEUROSCIENCE; PREFRONTAL CORTEX; ELECTRIC-FIELD; INTRAPARIETAL SULCUS; ONLINE ADJUSTMENTS; NEURONAL RESPONSES;

D O I：

10.1038/s41467-019-10638-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transcranial magnetic stimulation (TMS) can non-invasively modulate neural activity in humans. Despite three decades of research, the spatial extent of the cortical area activated by TMS is still controversial. Moreover, how TMS interacts with task-related activity during motor behavior is unknown. Here, we applied single-pulse TMS over macaque parietal cortex while recording single-unit activity at various distances from the center of stimulation during grasping. The spatial extent of TMS-induced activation is remarkably restricted, affecting the spiking activity of single neurons in an area of cortex measuring less than 2 mm in diameter. In task-related neurons, TMS evokes a transient excitation followed by reduced activity, paralleled by a significantly longer grasping time. Furthermore, TMS-induced activity and task-related activity do not summate in single neurons. These results furnish crucial experimental evidence for the neural effects of TMS at the single-cell level and uncover the neural underpinnings of behavioral effects of TMS.

引用

页数：11

共 83 条

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