Cytomegalovirus DNA in Semen and Blood Is Associated With Higher Levels of Proviral HIV DNA

被引：52
作者：
Gianella, Sara [1 ]
Anderson, Christy M. [1 ]
Vargas, Milenka V. [1 ]
Richman, Douglas D. [1 ,2 ]
Little, Susan J. [1 ]
Morris, Sheldon R. [1 ]
Smith, Davey M. [1 ,2 ]
机构：
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
[2] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 207卷 / 06期
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
cytomegalovirus; HIV DNA; latent reservoir; immune activation; early HIV infection; ANTIRETROVIRAL THERAPY; INFECTION; VIRUS; CELLS; REPLICATION; PERSISTENCE; DISEASE;
D O I：
10.1093/infdis/jis777
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.
引用
收藏
页码：898 / 902
页数：5
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