Cytomegalovirus DNA in Semen and Blood Is Associated With Higher Levels of Proviral HIV DNA

被引：52
作者：
Gianella, Sara [1 ]
Anderson, Christy M. [1 ]
Vargas, Milenka V. [1 ]
Richman, Douglas D. [1 ,2 ]
Little, Susan J. [1 ]
Morris, Sheldon R. [1 ]
Smith, Davey M. [1 ,2 ]
机构：
[1] Univ Calif San Diego, La Jolla, CA 92093 USA
[2] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2013年 / 207卷 / 06期
基金：
瑞士国家科学基金会; 美国国家卫生研究院;
关键词：
cytomegalovirus; HIV DNA; latent reservoir; immune activation; early HIV infection; ANTIRETROVIRAL THERAPY; INFECTION; VIRUS; CELLS; REPLICATION; PERSISTENCE; DISEASE;
D O I：
10.1093/infdis/jis777
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Over three-fourths of human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)-naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.
引用
收藏
页码：898 / 902
页数：5
相关论文
共 50 条
  • [1] Cytomegalovirus Replication in Semen Is Associated with Higher Levels of Proviral HIV DNA and CD4+ T Cell Activation during Antiretroviral Treatment
    Gianella, Sara
    Massanella, Marta
    Richman, Douglas D.
    Little, Susan J.
    Spina, Celsa A.
    Vargas, Milenka V.
    Lada, Steven M.
    Daar, Eric S.
    Dube, Michael P.
    Haubrich, Richard H.
    Morris, Sheldon R.
    Smith, Davey M.
    JOURNAL OF VIROLOGY, 2014, 88 (14) : 7818 - 7827
  • [2] Factors Associated with the Size of HIV DNA Reservoir
    Wang, Ni-Dan
    Li, Tai-Sheng
    CHINESE MEDICAL JOURNAL, 2017, 130 (02) : 224 - 230
  • [3] Early ART-initiation and longer ART duration reduces HIV-1 proviral DNA levels in children from the CHER trial
    Payne, Helen
    Chan, Man K.
    Watters, Sarah A.
    Otwombe, Kennedy
    Hsiao, Nei-Yuan
    Babiker, Abdel
    Violari, Avy
    Cotton, Mark F.
    Gibb, Diana M.
    Klein, Nigel J.
    AIDS RESEARCH AND THERAPY, 2021, 18 (01)
  • [4] Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits
    Kowalski, M. L.
    Wardzynska, A.
    Studzinska, M.
    Pawelczyk, M.
    Lesnikowski, Z. J.
    Paradowska, E.
    ALLERGY, 2017, 72 (12) : 2035 - 2038
  • [5] Comparison of HIV-1 DNA load measurements in blood and in relation to successful proviral sequencing
    Fuchs, Anne
    Wasser, Antoine
    Faua, Clayton
    Caspar, Stephanie
    Jegou, Frederic
    Velay, Aurelie
    Laugel, Elodie
    Ursenbach, Axel
    Rey, David
    Fafi-Kremer, Samira
    Gantner, Pierre
    INFECTIOUS DISEASES NOW, 2024, 54 (02):
  • [6] Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
    Simonetti, Francesco R.
    White, Jennifer A.
    Tumiotto, Camille
    Ritter, Kristen D.
    Cai, Mian
    Gandhi, Rajesh T.
    Deeks, Steven G.
    Howell, Bonnie J.
    Montaner, Luis J.
    Blankson, Joel N.
    Martin, Albine
    Laird, Gregory M.
    Siliciano, Robert F.
    Mellors, John W.
    Siliciano, Janet D.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (31) : 18692 - 18700
  • [7] Peripheral blood lymphocyte HIV DNA levels correlate with HIV associated neurocognitive disorders in Nigeria
    Jumare, Jibreel
    Sunshine, Sara
    Ahmed, Hayat
    El-Kamary, Samer S.
    Magder, Laurence
    Hungerford, Laura
    Burdo, Tricia
    Eyzaguirre, Lindsay M.
    Umlauf, Anya
    Cherner, Mariana
    Abimiku, Alash'le
    Charurat, Man
    Li, Jonathan Z.
    Blattner, William A.
    Royal, Walter, III
    JOURNAL OF NEUROVIROLOGY, 2017, 23 (03) : 474 - 482
  • [8] HIV RNA and proviral HIV DNA can be detected in semen after 6 months of antiretroviral therapy although HIV RNA is undetectable in blood
    Du, Peiwei
    Liu, An
    Jiao, Yanmei
    Liu, Cuie
    Jiang, Taiyi
    Zhu, Weijun
    Zhu, Yunxia
    Wu, Hao
    Sun, Lijun
    MICROBIOLOGY AND IMMUNOLOGY, 2016, 60 (03) : 187 - 195
  • [9] CRISPR-Cas attack of HIV-1 proviral DNA can cause unintended deletion of surrounding cellular DNA
    Liu, Ye
    Binda, Caroline S.
    Berkhout, Ben
    Das, Atze T.
    JOURNAL OF VIROLOGY, 2023, 97 (12)
  • [10] Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy
    Gandhi, Rajesh T.
    Cyktor, Joshua C.
    Bosch, Ronald J.
    Mar, Hanna
    Laird, Gregory M.
    Martin, Albine
    Collier, Ann C.
    Riddler, Sharon A.
    Macatangay, Bernard J.
    Rinaldo, Charles R.
    Eron, Joseph J.
    Siliciano, Janet D.
    McMahon, Deborah K.
    Mellors, John W.
    JOURNAL OF INFECTIOUS DISEASES, 2021, 223 (02) : 225 - 233
12345