Event-related potentials elicited during working memory are altered in mild cognitive impairment

被引：40
作者：
Zunini, Rocio A. Lopez [1 ,2 ]
Knoefel, Frank [2 ,3 ,4 ,5 ]
Lord, Courtney [2 ]
Dzuali, Fiatsogbe [1 ]
Breau, Michael [3 ]
Sweet, Lisa [2 ,3 ]
Goubran, Rafik [2 ,3 ,4 ]
Taler, Vanessa [1 ,2 ]
机构：
[1] Univ Ottawa, Sch Psychol, Vanier Hall,136 Jean Jacques Lussier, Ottawa, ON K1N 6N5, Canada
[2] Bruyere Res Inst, 75 Bruyere St, Ottawa, ON K1N 5C8, Canada
[3] Bruyere Continuing Care, Bruyere Memory Program, 43 Bruyere St, Ottawa, ON K1N 5C8, Canada
[4] Carleton Univ, Fac Engn & Design, Minto Ctr 3010, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada
[5] Univ Ottawa, Fac Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
来源：
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY | 2016年 / 109卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Mild cognitive impairment; Working memory; N-back; Event-related potentials; SHORT-TERM-MEMORY; GATING DEFICIT; ALZHEIMERS-DISEASE; FLUID INTELLIGENCE; EVOKED-POTENTIALS; MIDDLE-LATENCY; N-BACK; ATTENTION; P300; LOAD;
D O I：
10.1016/j.ijpsycho.2016.09.012
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
Persons with Mild Cognitive Impairment (MCI) can experience deficits in working memory. In the present study, we investigated working memory in persons with MCI and cognitively healthy older adults using event-related potentials (ERPs). Participants performed an n-back working memory task with baseline (0-back), low load (1-back), and high load (2-back) working memory conditions. MCI participants' performance was less accurate than that of healthy older adults in both the 1-back and 2-back conditions, and reaction times were longer in MCI than control participants in the 0-back, 1-back and 2-back conditions. ERP analyses revealed delayed P200 and N200 latencies and smaller P300 amplitudes in MCI relative to control participants in the 0-back, 1-back and 2-back conditions. Deterioration in working memory performance concomitant with marked electrophysiological alterations suggests that persons with MCI exhibit deficits in several cognitive processes that include early attention, stimulus discrimination and classification, and updating and manipulation of information held in working memory. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 8
页数：8
相关论文
共 55 条
[1]   Visual and visuospatial short-term memory in mild cognitive impairment and Alzheimer disease: Role of attention [J].
Alescio-Lautier, B. ;
Michel, B. F. ;
Herrera, C. ;
Elahmadi, A. ;
Chambon, C. ;
Touzet, C. ;
Paban, V. .
NEUROPSYCHOLOGIA, 2007, 45 (08) :1948-1960
[2]  
Ally Brandon A, 2006, Am J Alzheimers Dis Other Demen, V21, P439
[3]  
[Anonymous], INT J GERONTOL
[4]   Evidence for attentional gradient in the serial position memory curve from event-related potentials [J].
Azizian, Aflen ;
Polich, John .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2007, 19 (12) :2071-2081
[5]   Working memory [J].
Baddeley, Alan .
CURRENT BIOLOGY, 2010, 20 (04) :R136-R140
[6]  
Bashore T., 1990, Event Related Brain Potentials, P242
[7]   Working memory and control of attention in persons with Alzheimer's disease and mild cognitive impairment [J].
Belleville, Sylvie ;
Chertkow, Howard ;
Gauthier, Serge .
NEUROPSYCHOLOGY, 2007, 21 (04) :458-469
[8]   The Wisconsin Card Sorting Test and the N-back test in mild cognitive impairment and elderly depression [J].
Borkowska, Alina ;
Drozdz, Wiktor ;
Jurkowski, Piotr ;
Rybakowski, Janusz K. .
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2009, 10 (04) :870-876
[9]   Sensory gating deficit assessed by P50/Pb middle latency event related potential in Alzheimer's disease [J].
Cancelli, Iacopo ;
Cadore, Italo Pittaro ;
Merlino, Giovanni ;
Valentinis, Luca ;
Moratti, Ugo ;
Bergonzi, Paolo ;
Gigli, Gian Luigi ;
Valente, Mariarosaria .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2006, 23 (05) :421-425
[10]   Sensory gating: A translational effort from basic to clinical science [J].
Cromwell, Howard C. ;
Mears, Ryan P. ;
Wan, Li ;
Boutros, Nash N. .
CLINICAL EEG AND NEUROSCIENCE, 2008, 39 (02) :69-72
123456