Proton magnetic resonance spectroscopy in schizophrenia

被引：34
作者：
Bertolino, A [1 ]
Weinberger, DR [1 ]
机构：
[1] NIMH, Intramural Res Program, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA
来源：
EUROPEAN JOURNAL OF RADIOLOGY | 1999年 / 30卷 / 02期
关键词：
magnetic resonance spectroscopy; schizophrenia; spectral localization;
D O I：
10.1016/S0720-048X(99)00052-2
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Proton magnetic resonance spectroscopy (MRS) has become an important tool to study in vivo certain biochemical aspects of brain disorders. In the last decade this technique has been applied to the in vivo investigation of pathophysiological aspects of psychiatric disorders, extending knowledge of the related brain alterations. This review will focus on providing some background to clarify technical and biochemical issues and it will describe the studies that have been performed in schizophrenia. The results will be framed in a more general context to highlight what we have learned and what remains to be understood from the application of this technique to schizophrenia. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：132 / 141
页数：10
相关论文
共 55 条
  • [1] Akbarian S, 1996, J NEUROSCI, V16, P19
  • [2] QUANTITATIVE PROTON SPECTROSCOPY OF CANINE BRAIN - IN-VIVO AND IN-VITRO CORRELATIONS
    BARKER, PB
    BREITER, SN
    SOHER, BJ
    CHATHAM, JC
    FORDER, JR
    SAMPHILIPO, MA
    MAGEE, CA
    ANDERSON, JH
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1994, 32 (02) : 157 - 163
  • [3] Bartha R, 1997, ARCH GEN PSYCHIAT, V54, P959
  • [4] Inhibition of N-acetylaspartate production: Implications for H-1 MRS studies in vivo
    Bates, TE
    Strangward, M
    Keelan, J
    Davey, GP
    Munro, PMG
    Clark, JB
    [J]. NEUROREPORT, 1996, 7 (08) : 1397 - 1400
  • [5] Bertolino A, 1996, AM J PSYCHIAT, V153, P1554
  • [6] Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging
    Bertolino, A
    Kumra, S
    Callicott, JH
    Mattay, VS
    Lestz, RM
    Jacobsen, L
    Barnett, IS
    Duyn, JH
    Frank, JA
    Rapoport, JL
    Weinberger, DR
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 1998, 155 (10) : 1376 - 1383
  • [7] Regionally specific neuronal pathology in untreated patients with schizophrenia: A proton magnetic resonance spectroscopic imaging study
    Bertolino, A
    Callicott, JH
    Elman, I
    Mattay, VS
    Tedeschi, G
    Frank, JA
    Breier, A
    Weinberger, DR
    [J]. BIOLOGICAL PSYCHIATRY, 1998, 43 (09) : 641 - 648
  • [8] Bertolino A, 1998, NEUROPSYCHOPHARMACOL, V18, P1
  • [9] Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: A proton magnetic resonance spectroscopic imaging study
    Bertolino, A
    Saunders, RC
    Mattay, VS
    Bachevalier, J
    Frank, JA
    Weinberger, DR
    [J]. CEREBRAL CORTEX, 1997, 7 (08) : 740 - 748
  • [10] BERTOLINO A, 1999, BIOL PSYCHIAT
123456