Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer's Disease

被引：11
|
作者：
Wei Yan [1 ]
Miao Jun-Ye [1 ,2 ]
Liu Ying [1 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 39卷 / 08期
关键词：
endogenous and exogenous factors; Alzheimer's disease; Tau protein; abnormal phosphorylation; AMYLOID-BETA; OXIDATIVE STRESS; PROTEIN-TAU; NEUROFIBRILLARY DEGENERATION; CEREBROSPINAL-FLUID; RECENT PROGRESS; MOUSE MODEL; IN-VITRO; PHOSPHORYLATION; DYSFUNCTION;
D O I：
10.3724/SP.J.1206.2012.00365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurofibrillary tangles (NFTs) are regarded as one of the major pathological features of Alzheimer's disease, and are composed of misfolded and aggreagted Tau protein with hyperphosphorylation. But the mechanism of Tau hyperphosphorylation still remains to be clarified. This review summarized the roles of endogenous and exogenous factors in the induction of Tau hyperphosphorylation. The level of some factors and the hyperphosphorylation of Tau could be used as biomarkers for the early processing of AD.
引用
收藏
页码：778 / 784
页数：7
相关论文
共 80 条
  • [11] The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    Dickey, Chad A.
    Kamal, Adeela
    Lundgren, Karen
    Klosak, Natalia
    Bailey, Rachel M.
    Dunmore, Judith
    Ash, Peter
    Shoraka, Sareh
    Zlatkovic, Jelena
    Eckman, Christopher B.
    Patterson, Cam
    Dickson, Dennis W.
    Nahman, N. Stanley, Jr.
    Hutton, Michael
    Burrows, Francis
    Petrucelli, Leonard
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (03): : 648 - 658
  • [12] Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures
    Egaña, JT
    Zambrano, C
    Nuñez, MT
    Gonzalez-Billault, C
    Maccioni, RB
    [J]. BIOMETALS, 2003, 16 (01) : 215 - 223
  • [13] Tau Protein Phosphorylation in Diverse Brain Areas of Normal and CRH Deficient Mice: Up-Regulation by Stress
    Filipcik, Peter
    Novak, Petr
    Mravec, Boris
    Ondicova, Katarina
    Krajciova, Gabriela
    Novak, Michal
    Kvetnansky, Richard
    [J]. CELLULAR AND MOLECULAR NEUROBIOLOGY, 2012, 32 (05) : 837 - 845
  • [14] PHOSPHORYLATION OF TAU PROTEINS - A MAJOR EVENT DURING THE PROCESS OF NEUROFIBRILLARY DEGENERATION - A COMPARATIVE-STUDY BETWEEN ALZHEIMERS-DISEASE AND DOWNS-SYNDROME
    FLAMENT, S
    DELACOURTE, A
    MANN, DMA
    [J]. BRAIN RESEARCH, 1990, 516 (01) : 15 - 19
  • [15] GARVER TD, 1995, MOL PHARMACOL, V47, P745
  • [16] Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle
    Gentry, MS
    Hallberg, RL
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (10) : 3477 - 3492
  • [17] Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
    Goedert, M
    Jakes, R
    Spillantini, MG
    Hasegawa, M
    Smith, MJ
    Crowther, RA
    [J]. NATURE, 1996, 383 (6600) : 550 - 553
  • [18] Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease
    Hanger, Diane P.
    Seereeram, Anjan
    Noble, Wendy
    [J]. EXPERT REVIEW OF NEUROTHERAPEUTICS, 2009, 9 (11) : 1647 - 1666
  • [19] Formaldehyde stress
    He RongQiao
    Lu Jing
    Mia JunYe
    [J]. SCIENCE CHINA-LIFE SCIENCES, 2010, 53 (12) : 1399 - 1404
  • [20] Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis
    Ho, Yuen-Shan
    Yang, Xifei
    Lau, Jeffery Chi-Fai
    Hung, Clara Hui-Ling
    Wuwongse, Suthicha
    Zhang, Qishan
    Wang, Jianzhi
    Baum, Larry
    So, Kwok-Fai
    Chang, Raymond Chuen-Chung
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2012, 28 (04) : 839 - 854
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