Endogenous and Exogenous Factors in Hyperphosphorylation of Tau in Alzheimer's Disease

被引：11
|
作者：
Wei Yan [1 ]
Miao Jun-Ye [1 ,2 ]
Liu Ying [1 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 39卷 / 08期
关键词：
endogenous and exogenous factors; Alzheimer's disease; Tau protein; abnormal phosphorylation; AMYLOID-BETA; OXIDATIVE STRESS; PROTEIN-TAU; NEUROFIBRILLARY DEGENERATION; CEREBROSPINAL-FLUID; RECENT PROGRESS; MOUSE MODEL; IN-VITRO; PHOSPHORYLATION; DYSFUNCTION;
D O I：
10.3724/SP.J.1206.2012.00365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurofibrillary tangles (NFTs) are regarded as one of the major pathological features of Alzheimer's disease, and are composed of misfolded and aggreagted Tau protein with hyperphosphorylation. But the mechanism of Tau hyperphosphorylation still remains to be clarified. This review summarized the roles of endogenous and exogenous factors in the induction of Tau hyperphosphorylation. The level of some factors and the hyperphosphorylation of Tau could be used as biomarkers for the early processing of AD.
引用
收藏
页码：778 / 784
页数：7
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