Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

被引：149

作者：

Liu, Jianzhao ^{[1
]}

Zhu, Yuanxiang ^{[2
]}

Luo, Guan-Zheng ^{[1
]}

Wang, Xinxia ^{[1
,3
]}

Yue, Yanan ^{[1
]}

Wang, Xiaona ^{[2
]}

Zong, Xin ^{[3
]}

Chen, Kai ^{[1
]}

Yin, Hang ^{[1
]}

Fu, Ye ^{[1
]}

Han, Dali ^{[1
]}

Wang, Yizhen ^{[3
]}

Chen, Dahua ^{[2
]}

He, Chuan ^{[1
]}

机构：

[1] Univ Chicago, Inst Biophys Dynam, Howard Hughes Med Inst, Dept Chem,Dept Biochem & Mol Biol, 929 East 57th St, Chicago, IL 60637 USA

[2] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China

[3] Zhejiang Univ, Coll Anim Sci, Key Lab Anim Nutr & Feed Sci, Minist Agr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC-DEVELOPMENT; ELEMENTS; N-6-METHYLADENINE; N6-METHYLADENINE; N-6-ADENINE; SEQUENCES; GENOME;

D O I：

10.1038/ncomms13052

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

DNA N-6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to similar to 0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.

引用

页数：7

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