Neuroprotective effect of recombinant neutrophil inhibitory factor in transient focal cerebral ischaemia in the rat

被引：29

作者：

Mackay, KB

Bailey, SJ

King, PD

Patel, S

Hamilton, TC

Campbell, CA

机构：

[1] Department of Neurology Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park (North), Harlow, Essex CM19 5AW, Third Avenue

来源：

NEURODEGENERATION | 1996年 / 5卷 / 04期

关键词：

focal cerebral ischaemia; neuroprotection; neutrophils; reperfusion;

D O I：

10.1006/neur.1996.0043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroprotective effects of recombinant neutrophil inhibitory factor (NIF) have been assessed with temporary (2 h) middle cerebral artery (MCA) occlusion in the rat using the intraluminal suture technique. Administration of NIF (1.5 mg/kg, i.v.) immediately after the onset of reperfusion and at 4 and 6 h post-MCA occlusion significantly reduced both hemispheric infarct volume (P < 0.001) and brain swelling (P < 0.001), and improved neurological outcome (P < 0.02) when assessed at 24 h. These results demonstrate the marked neuroprotective efficacy of NIF in a rat model of transient focal cerebral ischaemia. (C) 1996 Academic Press Limited

引用

页码：319 / 323

页数：5

共 24 条

[1] REPERFUSION INCREASES NEUTROPHILS AND LEUKOTRIENE-B4 RECEPTOR-BINDING IN RAT FOCAL ISCHEMIA [J].

BARONE, FC ;

SCHMIDT, DB ;

HILLEGASS, LM ;

PRICE, WJ ;

WHITE, RF ;

FEUERSTEIN, GZ ;

CLARK, RK ;

LEE, EV ;

GRISWOLD, DE ;

SARAU, HM .

STROKE, 1992, 23 (09) :1337-1347

[2] RAT MIDDLE CEREBRAL-ARTERY OCCLUSION - EVALUATION OF THE MODEL AND DEVELOPMENT OF A NEUROLOGIC EXAMINATION [J].

BEDERSON, JB ;

PITTS, LH ;

TSUJI, M ;

NISHIMURA, MC ;

DAVIS, RL ;

BARTKOWSKI, H .

STROKE, 1986, 17 (03) :472-476

[3]

CHEN H, 1992, NEUROSCI RES COMMUN, V11, P93

[4] ANTI-CD11B MONOCLONAL-ANTIBODY REDUCES ISCHEMIC CELL-DAMAGE AFTER TRANSIENT FOCAL CEREBRAL-ISCHEMIA IN RAT [J].

CHEN, H ;

CHOPP, M ;

ZHANG, RL ;

BODZIN, G ;

CHEN, Q ;

RUSCHE, JR ;

TODD, RF .

ANNALS OF NEUROLOGY, 1994, 35 (04) :458-463

[5] POSTISCHEMIC ADMINISTRATION OF AN ANTI-MAC-1 ANTIBODY REDUCES ISCHEMIC CELL-DAMAGE AFTER TRANSIENT MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS [J].

CHOPP, M ;

ZHANG, RL ;

CHEN, H ;

LI, Y ;

JIANG, N ;

RUSCHE, JR .

STROKE, 1994, 25 (04) :869-875

[6] Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion - Role of neutrophil adhesion in the pathogenesis of stroke [J].

Connolly, ES ;

Winfree, CJ ;

Springer, TA ;

Naka, Y ;

Liao, H ;

Yan, SD ;

Stern, DM ;

Solomon, RA ;

GutierrezRamos, JC ;

Pinsky, DJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (01) :209-216

[7] NEUTROPHIL ENDOTHELIAL-CELL BINDING IN NEUTROPHIL-MEDIATED TISSUE-INJURY [J].

DELAOSSA, JC ;

MALAGO, M ;

GEWERTZ, BL .

JOURNAL OF SURGICAL RESEARCH, 1992, 53 (01) :103-107

[8]

GINSBERG MD, 1992, CEREBROVAS BRAIN MET, V4, P189

[9] Neutrophil inhibitory factor is neuroprotective after focal ischemia in rats [J].

Jiang, N ;

Moyle, M ;

Soule, HR ;

Rote, WE ;

Chopp, M .

ANNALS OF NEUROLOGY, 1995, 38 (06) :935-942

[10] THE LEUKOCYTE INTEGRINS [J].

KISHIMOTO, TK ;

LARSON, RS ;

CORBI, AL ;

DUSTIN, ML ;

STAUNTON, DE ;

SPRINGER, TA .

ADVANCES IN IMMUNOLOGY, 1989, 46 :149-182

← 1 2 3 →