Liver resection for liver metastases from nondigestive endocrine cancer: Extrahepatic disease burden defines outcome

被引:9
作者
Andreou, Andreas [1 ]
Brouquet, Antoine [1 ]
Bharathy, Kishore G. S. [1 ]
Perrier, Nancy D. [1 ]
Abdalla, Eddie K. [1 ]
Curley, Steven A. [1 ]
Glanemann, Matthias [2 ]
Seehofer, Daniel [2 ]
Neuhaus, Peter [2 ]
Vauthey, Jean-Nicolas [1 ]
Aloia, Thomas A. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[2] Charite, Dept Gen Visceral & Transplant Surg, Campus Virchow Klinikum, D-13353 Berlin, Germany
基金
美国国家卫生研究院;
关键词
COLORECTAL-CANCER; HEPATIC RESECTION; NEUROENDOCRINE METASTASES; NONNEUROENDOCRINE METASTASES; SURGICAL COMPLICATIONS; NONCOLORECTAL PRIMARY; HEPATECTOMY; SURVIVAL; CARCINOMA; TUMORS;
D O I
10.1016/j.surg.2011.12.025
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background. For patients with hepatic nondigestive endocrine metastases (HNEM), the role of liver resection is not well-defined. Methods. We reviewed outcomes for patients who underwent liver resection for HNEM at 2 centers to identify predictors of survival. Results. From 1991 to 2010, 51 patients underwent liver resection for HNEM. Primary tumor types were adrenal gland (n = 26), thyroid (n = 11), testicular germ cell (n = 9), and ovarian granulosa cell (n = 5). 28 patients (55 %) had synchronous or early (diagnosed within 12 months after primary tumor resection) liver metastases. At liver resection, 26 patients.(51%) had extrahepatic metastases, and 7 (14%) had >= 2 sites of extrahepatic metastases. 32 patients (63%) had major liver resection and 19 (37%) had a simultaneous extrahepatic procedure. 90-day postoperative morbidity and mortality rates were 27% and 2%, respectively. After median follow-up of 20 months (range, 1-144), the 5-year overall and recurrence-free survival rates were 58% and 37%, respectively. Survival was not affected by primary tumor type. In multivariate analysis, >= 2 sites of extrahepatic metastases (hazard ratio [HR] = 4.80; 95% confidence interval [CI] = 1.18-19.50; P = .028) and interval of <= 12 months between primary tumor resection and diagnosis of liver metastases (HR = 5.33; 95 % CI = 1.11-25.71; P = .037) were associated with worse overall survival after liver resection. Conclusion. For selected patients, liver resection for HNEM is associated with long-term survival. The number of extrahepatic sites of metastasis and the timing of appearance of liver metastases should be considered in patient selection. (Surgery 2012;151:851-9.)
引用
收藏
页码:851 / 859
页数:9
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