Dual function of sialic acid in gastrointestinal SARS-CoV-2 infection

被引：17

作者：

Engin, Ayse Basak ^{[1
]}

Engin, Evren Doruk ^{[2
]}

Engin, Atilla ^{[3
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Toxicol, TR-06330 Ankara, Turkey

[2] Ankara Univ, Biotechnol Inst, Gumusdere Campus, Ankara, Turkey

[3] Gazi Univ, Fac Med, Dept Gen Surg, Ankara, Turkey

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2020年 / 79卷

基金：

英国科研创新办公室;

关键词：

SARS-CoV-2; Sialic acid; Gut-lung axis; Chloroquine; ACE2; Faecal-oral route; ACUTE RESPIRATORY SYNDROME; TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS; SARS-CORONAVIRUS; S PROTEIN; SPIKE GLYCOPROTEIN; BOVINE CORONAVIRUS; AMINOPEPTIDASE-N; BINDING-ACTIVITY; VIRAL FUSION; RECEPTOR;

D O I：

10.1016/j.etap.2020.103436

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Recent analysis concerning the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- angiotensin converting enzyme (ACE) receptor interaction in enterocytes, the definition of gut-lung axis, as well as the molecular basis of sialic acid-related dual recognition concept in gastrointestinal SARS-CoV-2 infection, have brought a new perspective to potential therapeutic targets. In this review evolving research and clinical data on gastrointestinal SARS-CoV-2 infection are discussed in the context of viral fusion and entry mechanisms, focusing on the different triggers used by coronaviruses. Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine. In gastrointestinal SARS-CoV-2 infection the efficiency of these repositioned drugs is debated.

引用

页数：7

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