Is there a role for the ACE2 receptor in SARS-CoV-2 interactions with platelets?

被引：74

作者：

Campbell, Robert A. ^{[1
,2
,3
]}

Boilard, Eric ^{[4
,5
]}

Rondina, Matthew T. ^{[1
,2
,3
,6
,7
]}

机构：

[1] Univ Utah, Program Mol Med, Salt Lake City, UT USA

[2] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[4] Univ Laval, Ctr Rech, Ctr Hosp, Univ Quebec, Quebec City, PQ, Canada

[5] Univ Laval, Dept Microbiol Infectiol & Immunol, Quebec City, PQ, Canada

[6] George E Wahlen VAMC Dept Internal Med, Salt Lake City, UT USA

[7] GRECC, Salt Lake City, UT USA

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2021年 / 19卷 / 01期

基金：

加拿大健康研究院;

关键词：

ACE2; COVID-19; platelets; SARS-CoV-2; thrombosis; INFECTION; INVASION; CD147; CELLS; ENTRY;

D O I：

10.1111/jth.15156

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is an urgent need to understand the underlying mechanisms contributing to thrombotic and inflammatory complications during COVID-19. Data from independent groups have identified that platelets are hyperreactive during COVID-19. Platelet hyperreactivity is accompanied by changes in platelet gene expression, and enhanced interactions between platelets and leukocytes. In some patients, SARS-CoV-2 mRNA has been detected in platelets. Together, this suggests that SARS-CoV-2 may interact with platelets. However, controversy remains on which receptors mediate SARS-CoV-2 platelet interactions. Most, but not all, transcriptomic and proteomic analyses fail to observe the putative SARS-CoV-2 receptor, angiotensin converting enzyme-2, or the cellular serine protease necessary for viral entry, TMPRSS2, on platelets and megakaryocytes. Interestingly, platelets express other known SARS-CoV-2 receptors, which induce similar patterns of activation to those observed when platelets are incubated with SARS-CoV-2. This article explores these findings and discusses ongoing areas of controversy and uncertainty with regard to SARS-CoV-2 platelet interactions.

引用

页码：46 / 50

页数：5

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