NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats

被引：35
作者：
Zhang, Xiaoyu [1 ]
Wu, Huifeng [1 ]
Liao, Peiqiu [1 ]
Li, Xiaojing [1 ]
Ni, Jiazuan [1 ]
Pei, Fengkui [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, Key Lab Rare Earth Chem & Phys, Changchun 130022, Peoples R China
来源：
FOOD AND CHEMICAL TOXICOLOGY | 2006年 / 44卷 / 07期
基金：
中国国家自然科学基金;
关键词：
H-1 NMR spectroscopy; aristolochic acid; pattern recognition; biofluids; metabolites;
D O I：
10.1016/j.fct.2005.12.004
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The subacute toxicity of aristolochic acid (AA) was investigated by H-1 NMR spectroscopic and pattern recognition (PR)-based metabonomic methods. Model toxins were used to enable comparisons of the urinary profiles from rats treated with known toxicants and AA at various time intervals. Urinary H-1 NMR spectra were data-processed and analyzed by pattern recognition method. The result of visual comparison of the spectra showed that AA caused a renal proximal tubular and papillary lesion and a slight hepatic impair. Pattern recognition analysis indicated that the renal proximal tubule lesion was the main damage induced by AA, and the renal toxicity induced by AA was a progressive course with the accumulation of dosage by monitoring the toxicological processes from onset, development and part-recovery. These results were also supported by the conventional clinical biochemical parameters. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1006 / 1014
页数：9
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