Design of tetraplex specific ligands: cyclic naphthalene diimide

被引：33

作者：

Esaki, Yugo ^{[1
]}

Islam, Md. Monirul ^{[1
]}

Fujii, Satoshi ^{[2
]}

Sato, Shinobu ^{[1
,3
]}

Takenaka, Shigeori ^{[1
,3
]}

机构：

[1] Kyushu Inst Technol, Dept Appl Chem, Fukuoka 8048550, Japan

[2] Kyushu Inst Technol, Dept Biosci & Bioinformat, Iizuka, Fukuoka 8208502, Japan

[3] Kyushu Inst Technol, Res Ctr Biomicrosensing Technol, Fukuoka 8048550, Japan

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 45期

关键词：

TELOMERIC G-QUADRUPLEX; DNA; INTERCALATION; TOPOLOGY; SEQUENCE; CANCER; CELLS;

D O I：

10.1039/c4cc01005a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5'AGGG(TTAGGG)(3)-3' (K = 8.6 x 106 M-1) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5'-GGG AGG TTT CGC-3' and 3'-CCC TCC AAA GCG-5' (nK = 3.3 x 104 M-1) with 0.5 mu M of IC50 for telomerase activity.

引用

页码：5967 / 5969

页数：3

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