Human bocaviruses: Possible etiologic role in respiratory infection

被引:48
作者
Broccolo, Francesco [1 ]
Falcone, Valeria [2 ]
Esposito, Susanna [3 ]
Toniolo, Antonio [4 ,5 ]
机构
[1] Univ Milano Bicocca, Dept Hlth Sci, Milan, Italy
[2] Univ Freiburg, Dept Virol, Med Ctr, D-79104 Freiburg, Germany
[3] Univ Milan, Dept Pathophysiol & Transplantat, Pediat Highly Intens Care Unit, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy
[4] Univ Insubria, Lab Clin Microbiol, Osped Circolo, Varese, Italy
[5] Univ Insubria, Fdn Macchi, Varese, Italy
关键词
Bocavirus; Pathogenic role; Viremia; Respiratory virus; Enteric virus; Systemic manifestations; Persistent infection; Viral load; REAL-TIME PCR; VIRUS-LIKE PARTICLES; VIRAL-INFECTIONS; PARVOVIRUS B19; HOSPITALIZED CHILDREN; PEDIATRIC-PATIENTS; STEM-CELL; PREVALENCE; SEROEPIDEMIOLOGY; IDENTIFICATION;
D O I
10.1016/j.jcv.2015.09.008
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Four species of human bocaviruses (HBoV) are currently included in the Bocavirus genus. There is satisfactory evidence demonstrating an association between HBoV1 and respiratory disease in children, and there is evidence that HBoV2 (and possibly the HBoV3 and HBoV4 species) are associated with gastroenteritis. In particular, HBoV1 has been associated with a prolonged period of persistence in the mucosa of the respiratory tract. Virus persistence does play a role in the high frequency of co-infections with proper pathogens of the upper and lower respiratory tracts. The high detection rate of multiple respiratory viruses in up to 83% of respiratory specimens and the presence of asymptomatic HBoV1 infections complicate the elucidation of the pathogenic role of the agent. Overall, a large amount of data are available concerning HBoV1, whereas little information is available about other bocavirus species. High viral loads are often associated with symptoms, and viremia may be associated with systemic manifestations such as encephalopathy. The effects and mechanisms of latency, persistence, reactivation, and reinfection are poorly understood. Thus, particularly in co-infections, the pathogenic contribution of the detected bocavirus species cannot be accurately stated. This review summarizes the current knowledge of HBoV species and provides perspectives for future clinical studies. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:75 / 81
页数:7
相关论文
共 114 条
[21]   A novel integrated strategy for detection of human bocavirus based on a heminested PCR assay combined with boiling lysis method of samples in human specimens [J].
Chen, Long ;
Yao, Qing ;
Ma, Jing ;
Li, Jianning ;
Zhang, Qian ;
Yang, Yi ;
Li, Fang ;
Sun, Yuning .
JOURNAL OF VIROLOGICAL METHODS, 2014, 203 :48-53
[22]   Effects of Human Parvovirus B19 and Bocavirus VP1 Unique Region on Tight Junction of Human Airway Epithelial A549 Cells [J].
Chiu, Chun-Ching ;
Shi, Ya-Fang ;
Yang, Jiann-Jou ;
Hsiao, Yuan-Chao ;
Tzang, Bor-Show ;
Hsu, Tsai-Ching .
PLOS ONE, 2014, 9 (09)
[23]   The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005 [J].
Choi, Eun Hwa ;
Lee, Hoan Jong ;
Kim, Sun Jung ;
Eun, Byung Wook ;
Kim, Nam Hee ;
Lee, Jin A. ;
Lee, Jun Ho ;
Song, Eun Kyung ;
Park, So Hee Kim Ji Yong ;
Sung, Ji Yeon .
CLINICAL INFECTIOUS DISEASES, 2006, 43 (05) :585-592
[24]   Newly recognized bocaviruses (HBoV, HBoV2) in children and adults with gastrointestinal illness in the United States [J].
Chow, Brian D. W. ;
Ou, Zhen ;
Esper, Frank P. .
JOURNAL OF CLINICAL VIROLOGY, 2010, 47 (02) :143-147
[25]   The Human Bocaviruses: A Review and Discussion of Their Role in Infection [J].
Chow, Brian D. W. ;
Esper, Frank P. .
CLINICS IN LABORATORY MEDICINE, 2009, 29 (04) :695-+
[26]   Th1 and Th2 cytokine levels in nasopharyngeal aspirates from children with human bocavirus bronchiolitis [J].
Chung, Ju-Young ;
Han, Tae Hee ;
Kim, Jung-Sik ;
Kim, Sang Woo ;
Park, Chung-Gyu ;
Hwang, Eung-Soo .
JOURNAL OF CLINICAL VIROLOGY, 2008, 43 (02) :223-225
[27]   Parvovirus B19 Infection in Pregnancy [J].
Crane, Joan ;
Mundle, William ;
Boucoiran, Isabelle ;
Gagnon, Robert ;
Bujold, Emmanuel ;
Basso, Melanie ;
Bos, Hayley ;
Brown, Richard ;
Cooper, Stephanie ;
Gouin, Katy ;
McLeod, N. Lynne ;
Menticoglou, Savas ;
Mundle, William ;
Pylypjuk, Christy ;
Roggensack, Anne ;
Sanderson, Frank .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA, 2014, 36 (12) :1107-1116
[28]   Simultaneous detection of human bocavirus and adenovirus by multiplex real-time PCR in a Belgian paediatric population [J].
De Vos, N. ;
Vankeerberghen, A. ;
Vaeyens, F. ;
Van Vaerenbergh, K. ;
Boel, A. ;
De Beenhouwer, H. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2009, 28 (11) :1305-1310
[29]   Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively [J].
Deng, Xuefeng ;
Li, Yi ;
Qiu, Jianming .
JOURNAL OF VIROLOGICAL METHODS, 2014, 195 :112-119
[30]   Immunogenicity of recombinant human bocavirus-1,2 VP2 gene virus-like particles in mice [J].
Deng, Zhong-Hua ;
Hao, Ye-Xia ;
Yao, Li-Hong ;
Xie, Zhi-Ping ;
Gao, Han-Chun ;
Xie, Le-Yun ;
Zhong, Li-li ;
Zhang, Bing ;
Cao, You-De ;
Duan, Zhao-Jun .
IMMUNOLOGY, 2014, 142 (01) :58-66