Homer Proteins in Ca2+ Entry

被引：30
作者：
Jardin, Isaac [1 ]
Lopez, Jose J. [1 ]
Berna-Erro, Alejandro [1 ]
Salido, Gines M. [1 ]
Rosado, Juan A. [1 ]
机构：
[1] Univ Extremadura, Dept Physiol, Cellular Physiol Res Grp, Caceres 10071, Spain
来源：
IUBMB LIFE | 2013年 / 65卷 / 06期
关键词：
Homer; TRP channels; IP3R; PMCA; METABOTROPIC GLUTAMATE RECEPTORS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; HUMAN PLATELETS; CHANNEL ACTIVITY; RYANODINE RECEPTOR-TYPE-1; FUNCTIONAL INTERACTION; HIPPOCAMPAL-NEURONS; SCAFFOLD PROTEINS; PLASMA-MEMBRANE; SKELETAL-MUSCLE;
D O I：
10.1002/iub.1162
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms. Homer1 family presents an EVH1 domain, a coiled coil domain and two leucine zipper domains. Homer proteins regulate a number of Ca2+-handling proteins, including transient receptor potential channels and other Ca2+-permeable channels, ionotropic and metabotropic glutamate receptors, shank scaffolding proteins or endoplasmic reticulum Ca2+ release channels. This review article focuses on the association of Homer 1 proteins with Ca2+-handling proteins and their role on intracellular Ca2+-homeostasis. (C) 2013 IUBMB Life,
引用
收藏
页码：497 / 504
页数：8
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