Morphologically Virus-Like Fullerenol Nanoparticles Act as the Dual-Functional Nanoadjuvant for HIV-1 Vaccine

被引：123

作者：

Xu, Ligeng ^{[1
]}

Liu, Ye ^{[1
,3
]}

Chen, Zhiyun ^{[1
]}

Li, Wei ^{[2
]}

Liu, Ying

Wang, Liming ^{[1
,2
]}

Ma, Liying ^{[3
]}

Shao, Yiming ^{[3
]}

Zhao, Yuliang ^{[2
]}

Chen, Chunying ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

[3] Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, Div Res Virol & Immunol, Beijing 102206, Peoples R China

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 41期

基金：

对外科技合作项目（国际科技项目）;

关键词：

fullerenol; virus-like particle; nano-adjuvant; HIV-1; vaccine; YELLOW-FEVER VACCINE; POLY(GAMMA-GLUTAMIC ACID) NANOPARTICLES; TOLL-LIKE RECEPTORS; T-CELL MEMORY; IMMUNE-RESPONSES; INNATE IMMUNITY; RECOGNITION RECEPTORS; DENDRITIC CELLS; DNA; ADJUVANT;

D O I：

10.1002/adma.201300583

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fullerenol, which self-assembles into virus-sized nanoparticles, is designed as a dual-functional nanoadjuvant to generate comparable immune responses to the HIV DNA vaccine. It shows promising adjuvant activity via various immunization routes, decreasing the antigen dosage and immunization frequency while maintaining immunity levels and inducing TEM-biased immunity to combat the infection at early stage. The underlying mechanisms by which fullerenol-based formulation induces above-mentioned polyvalent immune responses are involved in activating multiple TLRs signaling pathways. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5928 / 5936

页数：9

共 56 条

[1]

Abbas AbulK., 2010, Basic Immunology: Functions and Disorders of the Immune System, V3rd

[2] Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without ''memory T cells''? [J].