Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

被引：0

作者：

Morais, GR

Oliveira, MCD

Thiemann, T ^{[1
]}

机构：

[1] Kyushu Univ, Inst Mat Chem & Engn, Kasuga, Fukuoka 8168580, Japan

[2] Univ Lisbon, Fac Pharm, P-1649 Lisbon, Portugal

[3] Inst Tecnol & Nucl, P-2686 Sacavem, Portugal

来源：

LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 03期

关键词：

estranes; steroids; conjugate addition; thermal dehydration;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of C7-substituted estra-1.3,5(10),6-tetraene-3,17 beta-diols were prepared as. precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17 beta-diols.

引用

页码：214 / 219

页数：6