Synthesis of C7-substituted estra-1,3,5(10),6-tetraen-3,17β-diols

被引：0
|
作者：
Morais, GR
Oliveira, MCD
Thiemann, T [1 ]
机构：
[1] Kyushu Univ, Inst Mat Chem & Engn, Kasuga, Fukuoka 8168580, Japan
[2] Univ Lisbon, Fac Pharm, P-1649 Lisbon, Portugal
[3] Inst Tecnol & Nucl, P-2686 Sacavem, Portugal
来源：
LETTERS IN ORGANIC CHEMISTRY | 2006年 / 3卷 / 03期
关键词：
estranes; steroids; conjugate addition; thermal dehydration;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of C7-substituted estra-1.3,5(10),6-tetraene-3,17 beta-diols were prepared as. precursors to radiodiagnostic agents of breast cancer. The introduction of the olefin moiety at C6/C7 in the molecules was achieved through thermal elimination of the 6-hydroxy group in the corresponding estra-1,3,5(10)-triene-3,17 beta-diols.
引用
收藏
页码：214 / 219
页数：6
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