It has to be the αv: myofibroblast integrins latent TGF-β1

被引：54

作者：

Hinz, Boris ^{[1
]}

机构：

[1] Univ Toronto, Fac Dent, Matrix Dynam Grp, Lab Tissue Repair & Regenerat, Toronto, ON, Canada

来源：

NATURE MEDICINE | 2013年 / 19卷 / 12期

关键词：

BETA; FIBROSIS;

D O I：

10.1038/nm.3421

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell-mediated activation of latent TGF-β1 is a key promoting event in fibrosis in all organs. A new study shows that specific targeting of the αv subunit of integrins in fibrogenic myofibroblasts effectively reduces developing and established fibrosis in liver, kidneys and lungs (pages 1617–1624). © 2013 Nature America, Inc. All rights reserved.

引用

页码：1567 / 1568

页数：2

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