Broken sleep predicts hardened blood vessels

被引：40
作者：
Vallat, Raphael [1 ]
Shah, Vyoma D. [1 ]
Redline, Susan [2 ,3 ]
Attia, Peter [4 ,5 ]
Walker, Matthew P. [1 ]
机构：
[1] Univ Calif Berkeley, Dept Psychol, Ctr Human Sleep Sci, 3210 Tolman Hall, Berkeley, CA 94720 USA
[2] Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA
[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
[4] Attia Med PC, San Diego, CA USA
[5] Attia Med PC, New York, NY USA
来源：
PLOS BIOLOGY | 2020年 / 18卷 / 06期
关键词：
NEUTROPHIL EXTRACELLULAR TRAPS; ARTERY-DISEASE; EEG AROUSALS; ATHEROSCLEROSIS; ASSOCIATION; DURATION; APNEA; FRAGMENTATION; CONSEQUENCES; CHOLESTEROL;
D O I：
10.1371/journal.pbio.3000726
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Why does poor-quality sleep lead to atherosclerosis? In a diverse sample of over 1,600 individuals, we describe a pathway wherein sleep fragmentation raises inflammatory-related white blood cell counts (neutrophils and monocytes), thereby increasing atherosclerosis severity, even when other common risk factors have been accounted for. Improving sleep quality may thus represent one preventive strategy for lowering inflammatory status and thus atherosclerosis risk, reinforcing public health policies focused on sleep health.
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页数：11
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