Nano-functionalization of metal complexes for molecular imaging and anticancer therapy

被引：71

作者：

Maldonado, Carmen R. ^{[1
]}

Salassa, Luca ^{[2
]}

Gomez-Blanco, Nina ^{[2
]}

Mareque-Rivas, Juan C. ^{[2
,3
]}

机构：

[1] Univ Edinburgh, EaStCHEM Sch Chem, Edinburgh, Midlothian, Scotland

[2] Cooperat Ctr Res Biomat CIC BiomaGUNE, San Sebastian 20009, Gipuzkoa, Spain

[3] Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain

来源：

COORDINATION CHEMISTRY REVIEWS | 2013年 / 257卷 / 19-20期

关键词：

Inorganic chemotherapeutics; Molecular imaging; Platinum drugs; Theranostics; Drug delivery; Drug activation; IRON-OXIDE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; MRI CONTRAST AGENTS; MULTIFUNCTIONAL MAGNETIC NANOPARTICLES; NANOSCALE COORDINATION POLYMERS; HOLLOW FE3O4 NANOPARTICLES; NEAR-INFRARED FLUORESCENT; WALLED CARBON NANOTUBES; PLGA-PEG NANOPARTICLES; GROWTH-FACTOR RECEPTOR;

D O I：

10.1016/j.ccr.2013.04.014

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Recently, there has been a growing interest in functionalizing metal complexes with biomolecules and nanomaterials for molecular imaging and anticancer therapy applications. In this review, we present the different strategies being used for inducing interaction and attachment of metal complexes to different types of biomolecules and nanomaterials. We explain and justify these new research efforts by considering the limitations of existing metal-based contrast agents and drugs as well as current challenges in therapy, diagnosis and visualization of biological processes at the molecular or cellular level. Representative examples in which nano-functionalisation of metal complexes enabled targeted delivery of small metal-based imaging probes, anti-cancer drugs and radiopharmaceuticals are used to illustrate the wide range of opportunities and challenges of this emerging approach. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：2668 / 2688

页数：21

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