Macromolecular MRI contrast agents: Structures, properties and applications

被引：132

作者：

Tang, Jianbin ^{[1
,2
]}

Sheng, Yuqi ^{[1
,2
]}

Hu, Hongjie ^{[3
]}

Shen, Youqing ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Key Lab Biomass Chem Engn, Minist Educ, Ctr Bionanoengn, Hangzhou 310027, Zhejiang, Peoples R China

[2] Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Dept Radiol, SRRSH, Hangzhou 310027, Zhejiang, Peoples R China

来源：

PROGRESS IN POLYMER SCIENCE | 2013年 / 38卷 / 3-4期

关键词：

Magnetic resonance imaging; Contrast agent; Macromolecular contrast agent; Dendrimer; Blood pool agent; Tumor imaging; GD-EOB-DTPA; MAGNETIC RESONANCE LYMPHANGIOGRAPHY; POLYAMIDOAMINE DENDRIMER CORE; TUMOR VASCULAR-PERMEABILITY; PEG CHAIN-LENGTH; WATER-EXCHANGE; GADOLINIUM CHELATE; MOLECULAR-WEIGHT; HIGH-RELAXIVITY; POLY(L-GLUTAMIC ACID);

D O I：

10.1016/j.progpolymsci.2012.07.001

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Stable gadolinium chelates are widely used as the contrast agents (CAs) for magnetic resonance imaging (MRI). Conjugation of the chelates onto macromolecular carriers forms macromolecular CAs (mCAs). Compared with small molecule MRI CAs, mCAs have advantages of high relaxivity and prolonged retention in blood circulation. Variants of mCAs have been synthesized and tested using animal models, showing their great potential applications in angiography, cancer imaging, kidney imaging, liver imaging, lymphatic imaging, and noninvasive visualization of drug delivery. Herein, the state of the art of mCAs, including their structures, properties, and applications is reviewed and future directions for developing mCAs are suggested. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：462 / 502

页数：41

共 180 条

[1] DYNAMIC CONTRAST-ENHANCED MR-IMAGING OF THE UPPER ABDOMEN - ENHANCEMENT PROPERTIES OF GADOBUTROL, GADOLINIUM-DTPA-POLYLYSINE, AND GADOLINIUM-DTPA-CASCADE-POLYMER [J].