Rapid determination of amphetamines by high-performance liquid chromatography with UV detection

被引：21

作者：

Sadeghipour, F

Giroud, C

Rivier, L

Veuthey, JL

机构：

[1] UNIV GENEVA,LAB CHIM ANALYT PHARMACEUT,CH-1211 GENEVA 4,SWITZERLAND

[2] UNIV LAUSANNE,INST MED LEGALE,LAB TOXICOL ANALYT,CH-1005 LAUSANNE,SWITZERLAND

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 761卷 / 1-2期

关键词：

forensic analysis; amphetamines; amines;

D O I：

10.1016/S0021-9673(96)00879-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A liquid chromatographic method with UV detection was developed for the separation and quantification of six amphetamines in the presence of adulterants in illicit drugs. Comparison was made between a regular reversed-phase and a base-deactivated column. The mobile phase composition was optimized by studying the influence of pH, buffer composition and the organic solvent type. Validation was accomplished by examination of the linearity, precision, accuracy, limits of detection and limits of quantification of the method. Amphetamines were quantified in eight tablets obtained from illicit drug seizures and the results were verified by a GC-MS procedure.

引用

页码：71 / 78

页数：8

共 29 条

[1]

BAKER DP, 1995, J FORENSIC SCI, V40, P108

[2]

DASGUPTA A, 1993, CLIN CHEM, V39, P104

[3] DRUG-TESTING IN THE WORKPLACE - COULD A POSITIVE TEST FOR ONE OF THE MANDATED DRUGS BE FOR REASONS OTHER THAN ILLICIT USE OF THE DRUG [J].