Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis

被引：140

作者：

Ferlauto, Laura ^{[1
]}

Leccardi, Marta Jole Ildelfonsa Airaghi ^{[1
]}

Chenais, Naig Aurelia Ludmilla ^{[1
]}

Gillieron, Samuel Charles Antoine ^{[1
]}

Vagni, Paola ^{[1
]}

Bevilacqua, Michele ^{[1
]}

Wolfensberger, Thomas J. ^{[2
]}

Sivula, Kevin ^{[3
]}

Ghezzi, Diego ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Sch Engn, Inst Bioengn, Ctr Neuroprosthet,Medtron Chair Neuroengn, Lausanne, Switzerland

[2] Univ Lausanne, Fdn Asile des Aveugles, Hop Ophtalm Jules Gonin, Dept Ophthalmol, Lausanne, Switzerland

[3] Ecole Polytech Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, Lab Mol Engn Optoelect Nanomat, Lausanne, Switzerland

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

RETINAL PROSTHESIS; ELECTRICAL-STIMULATION; MOBILITY PERFORMANCE; VISION; IMPLANTATION; RESTORATION; SAFETY;

D O I：

10.1038/s41467-018-03386-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye. We demonstrate that it is not cytotoxic and respects optical and thermal safety standards; accelerated ageing shows a lifetime of at least 2 years. POLYRETINA represents significant progress towards the improvement of both visual acuity and visual field with the same device, a current challenging issue in the field.

引用

页数：15

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