MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets

被引：8

作者：

Kotsinas, Athanassios ^{[1
]}

Sigala, Fragkiska ^{[2
]}

Garbis, Spiros D. ^{[3
,4
]}

Galyfos, Giorgos ^{[2
]}

Filis, Konstantinos ^{[2
]}

Vougas, Konstantinos ^{[5
]}

Papalampros, Alexandros ^{[6
]}

Johnson, Elizabeth E. ^{[7
]}

Chronopoulos, Efstathios ^{[8
]}

Georgakilas, Alexandros G. ^{[9
]}

Gorgoulis, Vassilis G. ^{[1
,5
,10
,11
]}

机构：

[1] Univ Athens, Sch Med, Dept Histol & Embryol, Mol Carcinogenesis Grp, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Propaedeut Surg 1, Hippocrate Hosp, GR-11527 Athens, Greece

[3] Univ Southampton, Fac Med, Ctr Proteome Res, Inst Life Sci,Canc Unit, Southampton SO9 5NH, Hants, England

[4] Univ Southampton, Fac Med, Ctr Proteome Res, Inst Life Sci,Clin Expt Sci Unit, Southampton SO9 5NH, Hants, England

[5] Acad Athens, Biomed Res Fdn, Athens, Greece

[6] Univ Athens, Laiko Hosp, Dept Surg 1, Athens, Greece

[7] Univ Athens, Sch Med, Dept Anat, GR-11527 Athens, Greece

[8] Konstantopoulio Hosp, Dept Orthopaed Surg, Athens, Greece

[9] Natl Tech Univ Athens, Dept Phys, Sch Appl Math & Phys Sci, GR-15773 Athens, Greece

[10] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Inst Canc Sci, Manchester, Lancs, England

[11] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Ctr Cellular Metab, Manchester, Lancs, England

来源：

CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 22期

关键词：

Biomarkers; cardiovascular disease; inflammation; miRNAs; ABDOMINAL AORTIC-ANEURYSM; CORONARY-ARTERY-DISEASE; COMMON FRAGILE SITES; SMOOTH-MUSCLE-CELLS; DNA-DAMAGE; IN-VIVO; ATHEROSCLEROTIC PLAQUES; CIRCULATING MICRORNAS; OXIDATIVE STRESS; GROWTH-FACTOR;

D O I：

10.2174/0929867322666150716113304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an initiating and driving component of CVDs.

引用

页码：2666 / 2679

页数：14

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