The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination

被引：2

作者：

Zago, Anna ^{[1
]}

Connolly, Sarah A. ^{[2
]}

Spear, Patricia G. ^{[1
]}

Longnecker, Richard ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

[2] DePaul Univ, Coll Sci & Hlth, Dept Hlth Sci, Chicago, IL USA

来源：

VIRUS RESEARCH | 2013年 / 171卷 / 01期

关键词：

Herpes simplex virus; Epstein-Barr virus; Glycoprotein B; Fusion; Entry; LINKER-INSERTION MUTAGENESIS; CRYSTAL-STRUCTURE; PSEUDORABIES VIRUS; HEPARAN-SULFATE; GD RECEPTOR; GH-GL; ENTRY; RESIDUES; COMPLEX; PROTEIN;

D O I：

10.1016/j.virusres.2012.10.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Among the herpesvirus glycoprotein B (gB) fusion proteins, the hydrophobic content of fusion loops and membrane proximal regions (MPRs) are inversely correlated with each other. We examined the functional importance of the hydrophobicity of these regions by replacing them in herpes simplex virus type 1 gB with corresponding regions from Epstein-Barr virus gB. We show that fusion activity is dependent on the structural context in which the specific loops and MPR sequences exist, rather than a simple hydrophobic relationship. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：227 / 230

页数：4

共 19 条

[1] Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL
Plate, Aileen E.
Reimer, Jessica J.
Jardetzky, Theodore S.
Longnecker, Richard
VIROLOGY, 2011, 413 (01) : 26 - 38
[2] Modulation of Epstein-Barr Virus Glycoprotein B (gB) Fusion Activity by the gB Cytoplasmic Tail Domain
Garcia, Nicholas J.
Chen, Jia
Longnecker, Richard
MBIO, 2013, 4 (01):
[3] The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes
Shelly, Spencer S.
Cairns, Tina M.
Whitbeck, J. Charles
Lou, Huan
Krummenacher, Claude
Cohen, Gary H.
Eisenberg, Roselyn J.
MBIO, 2012, 3 (06):
[4] Epstein-Barr Virus Glycoprotein gB and gHgL Can Mediate Fusion and Entry in trans, and Heat Can Act as a Partial Surrogate for gHgL and Trigger a Conformational Change in gB
Chesnokova, Liudmila S.
Ahuja, Munish K.
Hutt-Fletcher, Lindsey M.
JOURNAL OF VIROLOGY, 2014, 88 (21) : 12193 - 12201
[5] Herpes Simplex Virus Glycoprotein B Mutations Define Structural Sites in Domain I, the Membrane Proximal Region, and the Cytodomain That Regulate Entry
Fan, Qing
Longnecker, Richard
Connolly, Sarah A.
JOURNAL OF VIROLOGY, 2021, 95 (22)
[6] Membrane Requirement for Folding of the Herpes Simplex Virus 1 gB Cytodomain Suggests a Unique Mechanism of Fusion Regulation
Silverman, Jessica L.
Greene, Neil G.
King, David S.
Heldwein, Ekaterina E.
JOURNAL OF VIROLOGY, 2012, 86 (15) : 8171 - 8184
[7] Differential Effects on Cell Fusion Activity of Mutations in Herpes Simplex Virus 1 Glycoprotein B (gB) Dependent on Whether a gD Receptor or a gB Receptor Is Overexpressed
Fan, Qing
Lin, Erick
Satoh, Takeshi
Arase, Hisashi
Spear, Patricia G.
JOURNAL OF VIROLOGY, 2009, 83 (15) : 7384 - 7390
[8] Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity
Backovic, Marija
Jardetzky, Theodore S.
Longnecker, Richard
JOURNAL OF VIROLOGY, 2007, 81 (17) : 9596 - 9600
[9] Cleavage and Secretion of Epstein-Barr Virus Glycoprotein 42 Promote Membrane Fusion with B Lymphocytes
Sorem, Jessica
Jardetzky, Theodore S.
Longnecker, Richard
JOURNAL OF VIROLOGY, 2009, 83 (13) : 6664 - 6672
[10] The Amino Terminus of Herpes Simplex Virus Type 1 Glycoprotein K (gK) Modulates gB-Mediated Virus-Induced Cell Fusion and Virion Egress
Chouljenko, Vladimir N.
Iyer, Arun V.
Chowdhury, Sona
Chouljenko, Dmitry V.
Kousoulas, Konstantin G.
JOURNAL OF VIROLOGY, 2009, 83 (23) : 12301 - 12313

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