Comparison of essential oil components and in vitro anticancer activity in wild and cultivated Salvia verbenaca

被引：26
作者：
Russo, Alessandra [1 ]
Cardile, Venera [2 ]
Graziano, Adriana C. E. [2 ]
Formisano, Carmen [3 ]
Rigano, Daniela [3 ]
Canzoneri, Marisa [4 ]
Bruno, Maurizio [5 ]
Senatore, Felice [3 ]
机构：
[1] Univ Catania, Dept Drug Sci, Biochem Sect, I-95125 Catania, Italy
[2] Univ Catania, Dept Biomed Sci, I-95125 Catania, Italy
[3] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy
[4] Ente Sviluppo Agr Dipartimento Reg Azienda Forest, Palermo, Italy
[5] Univ Palermo, Dept Sci & Tecnol Biol Chim & Farrmaceut STEBICEF, I-90128 Palermo, Italy
来源：
NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 17期
关键词：
Salvia verbenaca; Lamiaceae; essential oil; sesquiterpenes; melanoma; apoptosis; CANCER-CELL LINES; CHEMICAL-COMPOSITION; GROWING WILD; OFFICINALIS L; APOPTOSIS; TUNISIA; LEAVES; DEATH;
D O I：
10.1080/14786419.2014.994212
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The objectives of our research were to study the chemical composition and the in vitro anticancer effect of the essential oil of Salvia verbenaca growing in natural sites in comparison with those of cultivated (Sc) plants. The oil from wild (Sw) S. verbenaca presented hexadecanoic acid (23.1%) as the main constituent, while the oil from Sc plants contained high quantities of hexahydrofarnesyl acetone (9.7%), scarce in the natural oil (0.7%). The growth-inhibitory and proapoptotic effects of the essential oils from Sw and Sc S. verbenaca were evaluated in the human melanoma cell line M14, testing cell vitality, cell membrane integrity, genomic DNA fragmentation and caspase-3 activity. Both the essential oils were able to inhibit the growth of the cancer cells examined inducing also apoptotic cell death, but the essential oil from cultivated samples exhibited the major effects.
引用
收藏
页码：1630 / 1640
页数：11
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