Metal-Free Oxidation of Thiols by N-Fluorobenzenesulfonimide: A Rapid and Efficient Method to Synthesize Disulfides

被引：4

作者：

Jing, Li ^{[1
,2
]}

Jin, Hui ^{[1
,2
]}

Guan, Mei ^{[3
]}

Wu, Xiaohua ^{[1
,2
]}

Wang, Qiantao ^{[1
,2
]}

Wu, Yong ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Chengdu 61004, Sichuan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 03期

基金：

中国国家自然科学基金;

关键词：

N-fluorobenzenesulfonimide; oxidation; disulfide; AEROBIC OXIDATION; SYMMETRICAL DISULFIDES; DIRECT SULFENYLATION; DIARYL DISULFIDES; MILD; RECEPTOR; PHTHALOCYANINE; VASOPRESSIN; DERIVATIVES; CATALYST;

D O I：

10.6023/cjoc201709039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and rapid method is developed for the oxidation of thiols to the corresponding disulfides using N-fluorobenzenesulfonimide (NFSI) as the oxidant without any contamination by over oxidation. The synthetic protocol for disulfide bond formation proceeded efficiently under external base-and metal-free conditions with the advantages of simple operation, mild reaction conditions as well as short reaction times.

引用

页码：692 / 697

页数：6

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