Physico-chemical and pharmaceutical characterization of sulindac-proglumide binary system

被引：3

作者：

Bruni, Giovanna ^{[1
]}

Sakaj, Mirena ^{[1
]}

Berbenni, Vittorio ^{[1
]}

Maggi, Lauretta ^{[2
]}

Friuli, Valeria ^{[2
]}

Girella, Alessandro ^{[1
]}

Milanese, Chiara ^{[1
]}

Marini, Amedeo ^{[1
]}

机构：

[1] Univ Pavia, CSGI Dept Chem, Phys Chem Sect, Viale Taramelli 16, I-27100 Pavia, Italy

[2] Univ Pavia, Dept Drug Sci, Viale Taramelli 12, I-27100 Pavia, Italy

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2019年 / 136卷 / 05期

关键词：

Sulindac; Proglumide; Eutectic; DSC; Dissolution rate; PHASE-DIAGRAMS;

D O I：

10.1007/s10973-018-7858-7

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Sulindac is a nonsteroidal anti-inflammatory drug with poor water solubility. This study presents a way to increase its dissolution rate while reducing the risk of gastrointestinal side effects. This approach considers the paired administration of sulindac with the gastroprotector proglumide, in the form of eutectic mixture. Theoretical and experimental methods proved that sulindac and proglumide form a simple eutectic system containing a molar fraction of proglumide of 0.7 at the eutectic point. The product with the eutectic composition, obtained by solvent evaporation, shows a significant improvement in the sulindac dissolution rate compared to the corresponding physical mixture.

引用

页码：2063 / 2070

页数：8

共 20 条

[1] [Anonymous], 2017, SUL OFF MON, P6283
[2] Phase diagram of ibuprofen with fatty acids
Benessam, S.
Khimeche, K.
Djellouli, F.
Benziane, M.
Dahmani, A.
[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2013, 112 (01) : 317 - 320
[3] SULINDAC - REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY IN RHEUMATIC DISEASES
BROGDEN, RN
HEEL, RC
SPEIGHT, TM
AVERY, GS
[J]. DRUGS, 1978, 16 (02) : 97 - 114
[4] Bruni G, J PHARM SCI UNPUB
[5] Fast dissolving eutectic compositions of two anti-tubercular drugs
Cherukuvada, Suryanarayan
Nangia, Ashwini
[J]. CRYSTENGCOMM, 2012, 14 (07): : 2579 - 2588
[6] Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World's Top Oral Drugs
Dahan, Arik
Miller, Jonathan M.
Amidon, Gordon L.
[J]. AAPS JOURNAL, 2009, 11 (04): : 740 - 746
[7] Polymorphism of sulindac: Isolation and characterization of a new polymorph and three new solvates
deIlarduya, MCT
Martin, C
Goni, MM
MartinezOharriz, MC
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (02) : 248 - 251
[8] Thermal, spectroscopic, and dissolution studies of the simvastatin-acetylsalicylic acid mixtures
Gorniak, Agata
Karolewicz, Bozena
Zurawska-Plaksej, Ewa
Pluta, Janusz
[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2013, 111 (03) : 2125 - 2132
[9] DSC study and phase diagrams calculation of binary systems of paracetamol
Klimova, K.
Leitner, J.
[J]. THERMOCHIMICA ACTA, 2012, 550 : 59 - 64
[10] Solid-state study of Captopril and Metoprolol Tartrate binary system
Marinescu, Daniela-Crina
Pincu, Elena
Oancea, Petruta
Bruni, Giovanna
Marini, Amedeo
Meltzer, Viorica
[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2015, 120 (01) : 829 - 837

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