Modeling Cancer with Flies and Fish

被引：55

作者：

Cagan, Ross L. ^{[1
]}

Zon, Leonard, I ^{[2
]}

White, Richard M. ^{[3
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Harvard Med Sch, Howard Hughes Med Inst, Childrens Hosp Boston, Boston, MA 02115 USA

[3] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期

关键词：

CAUSES GENOME INSTABILITY; ZEBRAFISH XENOTRANSPLANTATION; EXPOSURE ROUTES; SMALL MOLECULES; TUMOR-GROWTH; DROSOPHILA; NEOPLASIA; IDENTIFY; PLATFORM; TUMORIGENESIS;

D O I：

10.1016/j.devcel.2019.04.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer has joined heart disease as the leading source of mortality in the US. In an era of organoids, patient-derived xenografts, and organs on a chip, model organisms continue to thrive with a combination of powerful genetic tools, rapid pace of discovery, and affordability. Model organisms enable the analysis of both the tumor and its associated microenvironment, aspects that are particularly relevant to our understanding of metastasis and drug resistance. In this Perspective, we explore some of the strengths of fruit flies and zebrafish for addressing fundamental cancer questions and how these two organisms can contribute to identifying promising therapeutic candidates.

引用

页码：317 / 324

页数：8

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