In pursuit of the graft-versus-myeloma effect: A single institution experience

被引:2
作者
Gisella Galo-Hooker, Evelyn [1 ]
Jose Ruiz-Delgado, Guillermo [1 ,2 ,3 ]
Zamora-Ortiz, Gabriela [1 ,4 ]
Velazquez-Sanchez-de-Cima, Sara [1 ,3 ]
Jose Ruiz-Arguelles, Guillermo [1 ,2 ,3 ,4 ]
机构
[1] Clin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
[2] Clin Ruiz, Lab Clin Peubla, Peubla, Mexico
[3] Univ Popular Autonoma Estado Puebla, Puebla, Mexico
[4] Univ Amer, Puebla, Mexico
关键词
Allograft; Myeloma; Transplant; Reduced-intensity; MULTIPLE-MYELOMA; TRANSPLANTATION;
D O I
10.1179/1607845412Y.0000000041
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Partly because of a potential graft-versus-myeloma effect, allogeneic stem cell transplantation is a potentially curative treatment modality in patients with multiple myeloma (MM). Initial attempts have been hampered by the high transplant-related mortality in this setting. With a reduction of toxicity, allogeneic transplant approaches with reduced-intensity conditioning (RIC) have been utilized, although they are subjected to continued disease progression and relapse following transplantation. We analyze here the experience of allografting four patients with MM in a single institution, along a 16-year period in which a total of 152 individuals were allografted, using an RIC regimen; three of the patients have had previous autografts. All patients engrafted successfully and a graft-versus-myeloma effect was shown in all of them. One patient relapsed in the face of graft-versus-host disease (GVHD). Three patients have died (two as a result of GVHD) and one is alive with a limited form of chronic GVHD. The graft-versus-myeloma effect can be induced by means of allogeneic transplantation but the morbidity and mortality associated with the procedure leads into a relatively small proportion of MM patients being cured.
引用
收藏
页码:89 / 92
页数:4
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