机构:
Clin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
Univ Popular Autonoma Estado Puebla, Puebla, MexicoClin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
Velazquez-Sanchez-de-Cima, Sara
[1
,3
]
Jose Ruiz-Arguelles, Guillermo
论文数: 0引用数: 0
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机构:
Clin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
Clin Ruiz, Lab Clin Peubla, Peubla, Mexico
Univ Popular Autonoma Estado Puebla, Puebla, Mexico
Univ Amer, Puebla, MexicoClin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
Jose Ruiz-Arguelles, Guillermo
[1
,2
,3
,4
]
机构:
[1] Clin Ruiz, Ctr Hematol & Med Interna, Puebla, Mexico
[2] Clin Ruiz, Lab Clin Peubla, Peubla, Mexico
[3] Univ Popular Autonoma Estado Puebla, Puebla, Mexico
Partly because of a potential graft-versus-myeloma effect, allogeneic stem cell transplantation is a potentially curative treatment modality in patients with multiple myeloma (MM). Initial attempts have been hampered by the high transplant-related mortality in this setting. With a reduction of toxicity, allogeneic transplant approaches with reduced-intensity conditioning (RIC) have been utilized, although they are subjected to continued disease progression and relapse following transplantation. We analyze here the experience of allografting four patients with MM in a single institution, along a 16-year period in which a total of 152 individuals were allografted, using an RIC regimen; three of the patients have had previous autografts. All patients engrafted successfully and a graft-versus-myeloma effect was shown in all of them. One patient relapsed in the face of graft-versus-host disease (GVHD). Three patients have died (two as a result of GVHD) and one is alive with a limited form of chronic GVHD. The graft-versus-myeloma effect can be induced by means of allogeneic transplantation but the morbidity and mortality associated with the procedure leads into a relatively small proportion of MM patients being cured.