Immunohistochemical Analysis of Thrombi Retrieved During Treatment of Acute Ischemic Stroke Does Stent-Retriever Cause Intimal Damage?

被引：49

作者：

Singh, Paramdeep ^{[1
,2
]}

Doostkam, Soroush ^{[3
]}

Reinhard, Matthias ^{[4
]}

Ivanovas, Vera ^{[1
]}

Taschner, Christian A. ^{[1
]}

机构：

[1] Univ Hosp Freiburg, Dept Neuroradiol, D-79106 Freiburg, Germany

[2] Guru Gobind Singh Med Coll & Hosp, Dept Radiol, Faridkot, India

[3] Univ Hosp Freiburg, Inst Neuropathol, D-79106 Freiburg, Germany

[4] Univ Hosp Freiburg, Dept Neurol, D-79106 Freiburg, Germany

来源：

STROKE | 2013年 / 44卷 / 06期

关键词：

immunohistochemistry; ischemic stroke; thrombectomy; thrombus; THROMBECTOMY; THROMBOLYSIS; DEVICE;

D O I：

10.1161/STROKEAHA.113.000964

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-To provide evidence whether mechanical thrombectomy with stent-retrievers in the treatment of acute ischemic stroke causes intimal damage. Methods-This study analyzed thrombi retrieved by mechanical thrombectomy from cerebral arteries in 48 consecutive patients with acute ischemic stroke for the presence of endothelial cells using CD34 antibodies. Results-Of 48 thrombi analyzed, CD34-positive cells were absent in 20, present as isolated cells in 21, and found in clusters in 7 thrombi. We did not find any subendothelial vessel wall structures. Conclusions-Our findings suggest that mechanical thrombectomy with stent-retrievers does not cause relevant intimal damage in acute ischemic stroke treatment.

引用

页码：1720 / 1722

页数：3

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