SYNTHESIS OF CHIRAL TETRAHYDROISOQUINOLINE-DERIVED β-AMINO ALCOHOLS AND THEIR APPLICATION TO ASYMMETRIC REACTION

被引：0

作者：

Hari, Yoshiyuki ^{[1
]}

Sakuma, Masaki ^{[1
]}

Miyakawa, Ayako ^{[1
]}

Hatano, Keiichiro ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Nagoya, Aichi 4678603, Japan

来源：

HETEROCYCLES | 2008年 / 76卷 / 01期

关键词：

Amino Alcohol; Chiral Ligand; Diethylzinc; Enantioselective Addition; Tetrahydroisoquinoline;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three chiral 1,2,3,4-tetrahydroisoquinoline-derived beta-amino alcohols were synthesized by using the Ru-catalyzed asymmetric transfer hydrogenation C of 6-methoxy-1-(2-methoxyphenyl)-3,4-dihydroisoquinoline as the key reaction. The ability of the synthesized P-amino alcohols as chiral ligands was evaluated in the addition of diethylzinc to benzaldehyde.

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页码：305 / 311

页数：7

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