How Degrading: Cyp26s in Hindbrain Development

被引：76
作者：
White, Richard J. [2 ]
Schilling, Thomas F. [1 ]
机构：
[1] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
[2] Wellcome Trust Sanger Inst, Cambridge, England
来源：
DEVELOPMENTAL DYNAMICS | 2008年 / 237卷 / 10期
关键词：
retinoic acid; vitamin A; VAD; Cyp26; cytochrome p450; hindbrain; rhombomeres; hox genes;
D O I：
10.1002/dvdy.21695
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The vitamin A derivative retinoic acid performs many functions in vertebrate development and is thought to act as a diffusible morphogen that patterns the anterior-posterior axis of the hindbrain. Recent work in several systems has led to insights into how the spatial distribution of retinoic acid is regulated. These have shown local control of synthesis and degradation, and computational models suggest that degradation by the Cyp26 enzymes plays a critical role in the formation of a morphogen gradient as well as its ability to compensate for fluctuations in RA levels. Developmental Dynamics 237:2775-2790, 2008. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码：2775 / 2790
页数：16
相关论文
共 138 条
  • [1] The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
    Abu-Abed, S
    Dollé, P
    Metzger, D
    Beckett, B
    Chambon, P
    Petkovich, M
    [J]. GENES & DEVELOPMENT, 2001, 15 (02) : 226 - 240
  • [2] Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis
    Abu-Abed, S
    MacLean, G
    Fraulob, V
    Chambon, P
    Petkovich, M
    Dollé, P
    [J]. MECHANISMS OF DEVELOPMENT, 2002, 110 (1-2) : 173 - 177
  • [3] Developing with lethal RA levels:: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1
    Abu-Abed, S
    Dollé, P
    Metzger, D
    Wood, C
    MacLean, G
    Chambon, P
    Petkovich, M
    [J]. DEVELOPMENT, 2003, 130 (07): : 1449 - 1459
  • [4] AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells
    Agarwal, C
    Chandraratna, RAS
    Johnson, AT
    Rorke, EA
    Eckert, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12209 - 12212
  • [5] Begemann G, 2001, DEVELOPMENT, V128, P3081
  • [6] Beyond the neckless phenotype:: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain
    Begemann, G
    Marx, M
    Mebus, K
    Meyer, A
    Bastmeyer, M
    [J]. DEVELOPMENTAL BIOLOGY, 2004, 271 (01) : 119 - 129
  • [7] Differential distribution of retinoic acid synthesis in the chicken embryo as determined by immunolocalization of the retinoic acid synthetic enzyme, RALDH-2
    Berggren, K
    McCaffery, P
    Dräger, U
    Forehand, CJ
    [J]. DEVELOPMENTAL BIOLOGY, 1999, 210 (02) : 288 - 304
  • [8] Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymes
    Blentic, A
    Gale, E
    Maden, M
    [J]. DEVELOPMENTAL DYNAMICS, 2003, 227 (01) : 114 - 127
  • [9] Blumberg B, 1997, DEVELOPMENT, V124, P373
  • [10] OVEREXPRESSION OF THE CELLULAR RETINOIC ACID BINDING PROTEIN-I (CRABP-I) RESULTS IN A REDUCTION IN DIFFERENTIATION-SPECIFIC GENE-EXPRESSION IN F9 TERATOCARCINOMA CELLS
    BOYLAN, JF
    GUDAS, LJ
    [J]. JOURNAL OF CELL BIOLOGY, 1991, 112 (05) : 965 - 979
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