How Degrading: Cyp26s in Hindbrain Development

被引：76

作者：

White, Richard J. ^{[2
]}

Schilling, Thomas F. ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

[2] Wellcome Trust Sanger Inst, Cambridge, England

来源：

DEVELOPMENTAL DYNAMICS | 2008年 / 237卷 / 10期

关键词：

retinoic acid; vitamin A; VAD; Cyp26; cytochrome p450; hindbrain; rhombomeres; hox genes;

D O I：

10.1002/dvdy.21695

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The vitamin A derivative retinoic acid performs many functions in vertebrate development and is thought to act as a diffusible morphogen that patterns the anterior-posterior axis of the hindbrain. Recent work in several systems has led to insights into how the spatial distribution of retinoic acid is regulated. These have shown local control of synthesis and degradation, and computational models suggest that degradation by the Cyp26 enzymes plays a critical role in the formation of a morphogen gradient as well as its ability to compensate for fluctuations in RA levels. Developmental Dynamics 237:2775-2790, 2008. (C) 2008 Wiley-Liss, Inc.

引用

页码：2775 / 2790

页数：16

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