Al2O3 Microresonator Based Passive and Active Biosensors

被引：0

作者：

de Goede, Michiel ^{[1
]}

Chang, Lantian ^{[1
]}

Dijkstra, Meindert ^{[1
]}

Obregon, Raquel ^{[2
]}

Ramon-Azcon, Javier ^{[2
]}

Martinez, Elena ^{[2
]}

Padilla, Laura ^{[3
]}

Adan, Jaume ^{[3
]}

Mitjans, Francesc ^{[3
]}

Garcia-Blanco, Sonia M. ^{[1
]}

机构：

[1] Univ Twente, MESA Inst Nanotechnol, Opt Sci Grp, POB 217, NL-7500 AE Enschede, Netherlands

[2] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia, Baldiri Reixac 10-12, Barcelona 08028, Spain

[3] LEITAT Technol Ctr, Hlth & Biomed Unit, Baldiri Reixac 15-21, Barcelona 08028, Spain

来源：

2018 20TH ANNIVERSARY INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS (ICTON) | 2018年

基金：

欧盟地平线“2020”;

关键词：

aluminium oxide; ytterbium; microresonator; optical sensing; SILICON;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Al2O3 microresonators were realized for sensing applications of both passive and active devices. Passive microring resonators exhibited quality factors up to 3.2 x10(5) in air. A bulk refractive index sensitivity of 100 nm/RIU was demonstrated together with a limit of detection of 10(-6) RIU. Functionalizing their surface allowed for the label-free detection of the biomarker rhS100A4 from urine with a limit of detection of 3 nM. Furthermore, single-mode Al2O3:Yb3+ microdisk lasers were realized that could operate in an aqueous environment. Upon varying the bulk refractive index their lasing wavelength could be tuned with a sensitivity of 20 nm/RIU and a LOD of 3 x10(-6) RIU.

引用

页数：4

共 8 条

[1] Photonic generation of stable microwave signals from a dual-wavelength Al2O3:Yb3+ distributed-feedback waveguide laser [J].

Bernhardi, E. H. ;

Khan, M. R. H. ;

Roeloffzen, C. G. H. ;

van Wolferen, H. A. G. M. ;

Worhoff, K. ;

de Ridder, R. M. ;

Pollnau, M. .

OPTICS LETTERS, 2012, 37 (02) :181-183

[2] Intra-laser-cavity microparticle sensing with a dual-wavelength distributed-feedback laser [J].

Bernhardi, Edward H. ;

van der Werf, Kees O. ;

Hollink, Anton J. F. ;

Worhoff, Kerstin ;

de Ridder, Rene M. ;

Subramaniam, Vinod ;

Pollnau, Markus .

LASER & PHOTONICS REVIEWS, 2013, 7 (04) :589-595

[3] Silicon microring resonators [J].

Bogaerts, Wim ;

De Heyn, Peter ;

Van Vaerenbergh, Thomas ;

De Vos, Katrien ;

Selvaraja, Shankar Kumar ;

Claes, Tom ;

Dumon, Pieter ;

Bienstman, Peter ;

Van Thourhout, Dries ;

Baets, Roel .

LASER & PHOTONICS REVIEWS, 2012, 6 (01) :47-73

[4] Integrated Al2O3:Er3+ ring lasers on silicon with wide wavelength selectivity [J].

Bradley, J. D. B. ;

Stoffer, R. ;

Agazzi, L. ;

Ay, F. ;

Worhoff, K. ;

Pollnau, M. .

OPTICS LETTERS, 2010, 35 (01) :73-75

[5] A SiON Microring Resonator-Based Platform for Biosensing at 850 nm [J].

Samusenko, Alina ;

Gandolfi, Davide ;

Pucker, Georg ;

Chalyan, Tatevik ;

Guider, Romain ;

Ghulinyan, Mher ;

Pavesi, Lorenzo .

JOURNAL OF LIGHTWAVE TECHNOLOGY, 2016, 34 (03) :969-977

[6] Urine S100 proteins as potential biomarkers of lupus nephritis activity [J].

Turnier, Jessica L. ;

Fall, Ndate ;

Thornton, Sherry ;

Witte, David ;

Bennett, Michael R. ;

Appenzeller, Simone ;

Klein-Gitelman, Marisa S. ;

Grom, Alexei A. ;

Brunner, Hermine I. .

ARTHRITIS RESEARCH & THERAPY, 2017, 19 :242

[7] TriPleX: a versatile dielectric photonic platform [J].

Worhoff, Kerstin ;

Heideman, Rene G. ;

Leinse, Arne ;

Hoekman, Marcel .

ADVANCED OPTICAL TECHNOLOGIES, 2015, 4 (02) :189-207

[8] Reliable Low-Cost Fabrication of Low-Loss Al2O3:Er3+ Waveguides With 5.4-dB Optical Gain [J].

Worhoff, Kerstin ;

Bradley, Jonathan D. B. ;

Ay, Feridun ;

Geskus, Dimitri ;

Blauwendraat, Tom P. ;

Pollnau, Markus .

IEEE JOURNAL OF QUANTUM ELECTRONICS, 2009, 45 (5-6) :454-461

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