Linezolid Surveillance Results for the United States: LEADER Surveillance Program 2011

被引:39
作者
Flamm, Robert K. [1 ]
Mendes, Rodrigo E. [1 ]
Ross, James E. [1 ]
Sader, Helio S. [1 ]
Jones, Ronald N. [1 ,2 ]
机构
[1] JMI Labs, N Liberty, IA USA
[2] Tufts Univ, Sch Med, Boston, MA 02111 USA
关键词
SPECTRUM ANALYSIS; MEDICAL-CENTERS; NOSOCOMIAL PNEUMONIA; VANCOMYCIN; INFECTIONS;
D O I
10.1128/AAC.02112-12
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The LEADER surveillance program monitors the in vitro activity of linezolid and comparator agents against Gram-positive bacteria in the United States. In its eighth consecutive year ( 2011), a total of 60 medical centers from the United States, including seven medical centers specializing in children's health care contributed a total of 7,303 Gram-positive pathogens. The MIC90 value for Staphylococcus aureus was 2 mu g/ml, and for coagulase-negative staphylococci, enterococci, Streptococcus pneumoniae, beta-hemolytic streptococci, and viridans group streptococci, the MIC90 was 1 mu g/ml. The "all organism" linezolid-resistant and nonsusceptible rate was only 0.19%.
引用
收藏
页码:1077 / 1081
页数:5
相关论文
共 19 条
[1]  
Clinical and Laboratory Standards Institute, 2012, M02A11 CLIN LAB STA
[2]  
Clinical and Laboratory Standards Institute, 2012, M100S22 CLIN LAB STA
[3]  
Clinical and Laboratory Standards Institute, 2012, M07A9 CLIN LAB STAND
[4]   In vitro activity of linezolid against key gram-positive organisms isolated in the United States: Results of the LEADER 2004 surveillance program [J].
Draghi, DC ;
Sheehan, DJ ;
Hogan, P ;
Sahm, DF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (12) :5024-5032
[5]   Current antimicrobial resistance profiles among methicillin-resistant Staphylococcus aureus encountered in the outpatient setting [J].
Draghi, Deborah C. ;
Sheehan, Daniel F. ;
Hogan, Patricia ;
Sahm, Daniel F. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2006, 55 (02) :129-133
[6]   LEADER Program Results for 2009: an Activity and Spectrum Analysis of Linezolid Using 6,414 Clinical Isolates from 56 Medical Centers in the United States [J].
Farrell, David J. ;
Mendes, Rodrigo E. ;
Ross, James E. ;
Sader, Helio S. ;
Jones, Ronald N. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (08) :3684-3690
[7]   Linezolid surveillance program results for 2008 (LEADER Program for 2008) [J].
Farrell, David J. ;
Mendes, Rodrigo E. ;
Ross, James E. ;
Jones, Ronald N. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2009, 65 (04) :392-403
[8]   LEADER Surveillance program results for 2010: an activity and spectrum analysis of linezolid using 6801 clinical isolates from the United States (61 medical centers) [J].
Flamm, Robert K. ;
Farrell, David J. ;
Mendes, Rodrigo E. ;
Ross, James E. ;
Sader, Helio S. ;
Jones, Ronald N. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2012, 74 (01) :54-61
[9]   LEADER surveillance program results for 2006: an activity and spectrum analysis of linezolid using clinical isolates from the United States (50 medical centers) [J].
Jones, Ronald N. ;
Fritsche, Thomas R. ;
Sader, Helio S. ;
Ross, James E. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2007, 59 (03) :309-317
[10]   United States resistance surveillance results for linezolid (LEADER Program for 2007) [J].
Jones, Ronald N. ;
Ross, James E. ;
Castanheira, Mariana ;
Mendes, Rodrigo E. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2008, 62 (04) :416-426