Taurine as a green bio-organic catalyst for the preparation of bio-active barbituric and thiobarbituric acid derivatives in water media

被引：66
作者：
Daneshvar, Nader [1 ]
Shirini, Farhad [1 ,2 ]
Langarudi, Mohaddeseh Safarpoor Nikoo [2 ]
Karimi-Chayjani, Reyhaneh [1 ]
机构：
[1] Univ Guilan, Dept Chem, Univ Campus 2, Rasht 4133519141, Iran
[2] Univ Guilan, Dept Chem, Coll Sci, Rasht, Iran
来源：
BIOORGANIC CHEMISTRY | 2018年 / 77卷
基金：
美国国家科学基金会;
关键词：
Bio-organic catalyst; Taurine; 5-Arylidene (thio)barbituric acids, pyrano[2,3-d]pyrimidinone(thione); Water media; PROMOTED KNOEVENAGEL CONDENSATION; IONIC LIQUID; EFFICIENT CATALYST; AROMATIC-ALDEHYDES; NANOPARTICLES; PYRIMIDINONE;
D O I：
10.1016/j.bioorg.2017.12.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Taurine, a beta-amino acid that is abundantly available in the tissues of human and animals, is efficiently used as a green bio-organic catalyst in the preparation of some of the biologically active barbituric and thiobarbituric acid derivatives. In the presence of taurine, 5-Arylidene (thio) barbituric acid derivatives were prepared via Knovenagel reaction between aldehydes and (thio)barbituric acid. Using this reagent also pyrano[2,3-d]pyrimidinone(thione) derivatives were synthesized through a three -component reaction between aldehydes, (thio)barbituric and malononitrile. Both reactions are performed in water with good to excellent yields during acceptable reaction times. No organic solvent was used during reaction or separation steps and no extra-purification was exerted. Meanwhile, reusability of taurine was easy and noticeably high. (C) 2017 Elsevier Inc. All rights reserved.
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收藏
页码：68 / 73
页数：6
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