Chemical Composition and Antimicrobial Activity of Ageratina deltoidea

被引：16

作者：

Arciniegas, Amira ^{[1
]}

Perez-Castorena, Ana L. ^{[1
]}

Melendez-Aguirre, Mariana ^{[1
]}

Guillermo Avila, Jose ^{[2
]}

Maria Garcia-Bores, Ana ^{[2
]}

Luis Villasenor, Jose ^{[3
]}

Romo de Vivar, Alfonso ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Lab Fitoquim, Unidad Biol Tecnol & Prototipos UBIPRO, FES Iztacala, Tlalnepantla 54090, Estado De Mexic, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Biol, Circuito Exterior, Ciudad Univ, Mexico City 04510, DF, Mexico

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 03期

关键词：

sesquiterpene lactones; benzylbenzoate derivatives; ent-kaurenoid derivatives; antifungal activity; antibacterial activity; ANTIBACTERIAL ACTIVITIES; EUPATORIUM-DELTOIDEUM; CONSTITUENTS; DERIVATIVES; ACIDS; ANTIOXIDANT; ANTIFUNGAL; FLAVONOIDS; TERPENOIDS; LIGNANS;

D O I：

10.1002/cbdv.201700529

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical study of Ageratina deltoidea afforded grandiflorenic acid (1), ent-kaurenoic acid (2), and eight benzylbenzoates (3-10), two of them, 3,5-dimethoxybenzyl 2,3,6-trimethoxybenzoate (5) and 4-(-d-glucopyranosyloxy)-3-hydroxybenzyl 2,6-dimethoxybenzoate (9), described for the first time. In addition, the new sesquiterpene lactone deltoidin C (13), together with the known 11 and 12, the phenolic compounds: ayanin, 2,6-dimethoxybenzoic acid, methyl 3,4-dihydroxycinnamate, chlorogenic acid, and 3,5-dicaffeoylquinic acid were also isolated. The structures of these compounds were determined by spectroscopic methods and chemical reactions. The antibacterial and antifungal activities of compounds 1-12 were evaluated on Staphylococcus aureus, Escherichia coli, and Candida albicans. Deltoidin A (11) was the most active antibacterial agent (MIC 16.0gml(-1)) against E.coli, and the ent-kaurenoid derivatives (1-2) showed activity (MIC 31.0gml(-1)) against S.aureus.

引用

页数：7

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