CONDENSED ISOQUINOLINES 30. ACYLATION AND ALKYLATION OF 5,13-DIHYDRO-11H-ISOQUINO-[3,2-b]QUINAZOLIN-11-ONE

被引：2

作者：

Potikha, L. M. ^{[1
]}

Gutsul, R. M. ^{[1
]}

Kovtunenko, V. A. ^{[1
]}

Dubinina, G. G. ^{[1
]}

Tolmachev, A. A. ^{[1
]}

机构：

[1] Taras Shevchenko Kiev Natl Univ, UA-01033 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2008年 / 44卷 / 05期

关键词：

2a; 7a-diazacyclopenta[fg]naphthacene; enamines; isoquino[3,2-b]quinazoline; acylation; alkylation;

D O I：

10.1007/s10593-008-0078-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It was shown that 6-acyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-ones are formed when 5,13-dihydro- 11H-isoquino[3,2-b]quinazolin-11-one is heated with the chlorides and anhydrides of carboxylic acids in the presence of bases (pyridine, NaOAc) while 5-acyl-5,13-dihydro-11H-isoquino[ 3,2-b]quinazolin-11-ones are formed in the presence of NaH. In the presence of NaH 6-acyl-5,13- dihydro-11H-isoquino[3,2-b]quinazolin-11-ones form the products from acylation and alkylation at position 5. The action of heat on 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one in oxalyl chloride leads to 7H,8H-2a, 7a-diazacyclopenta[fg]naphthacene-1,2,8-trione.

引用

页码：585 / 593

页数：9

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