Challenging Regional Psoriasis and Ustekinumab Biotherapy: Impact of the Patterns of Disease

被引：7

作者：

Hermanns-Le, Trinh ^{[1
]}

Berardesca, Enzo ^{[2
]}

Pierard, Gerald E. ^{[1
]}

Lesuisse, Marianne ^{[3
]}

Pierard-Franchimont, Claudine ^{[1
,4
]}

机构：

[1] Univ Hosp Liege, Dept Dermatopathol, B-4000 Liege, Belgium

[2] San Gallicano Dermatol Inst, I-00144 Rome, Italy

[3] Reg Hosp Citadelle, Dept Dermatol, B-4000 Liege, Belgium

[4] Reg Hosp Huy, Dept Dermatol, B-4500 Huy, Belgium

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

QUALITY-OF-LIFE; NAIL PSORIASIS; PALMOPLANTAR PSORIASIS; SCALP PSORIASIS; OPEN-LABEL; OPTICAL PROFILOMETRY; CLINICALLY IMPORTANT; DOUBLE-BLIND; THERAPY; HAIR;

D O I：

10.1155/2012/413767

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In some patients, psoriasis appears refractory to many treatments, particularly when the disease is confined to some specific body regions. In this respect, palmoplantar psoriasis and palmoplantar pustulosis are possibly related conditions in their immunopathomechanisms involving Il-12, IL-23, and Th17. Nail psoriasis and scalp psoriasis are two other particular psoriasis manifestations. Accordingly, ustekinumab was tested in a few of these patients. The present paper is limited to peer-reviewed case reports. Data were not supported by bioinstrumental assessments and controlled trials. Overall, they are indicative of potential efficacy. The cost-effectiveness and the risk-benefit assessments merit further investigations.

引用

页数：6

共 66 条

[1]

[Anonymous], COCHRANE DATABASE SY

[2]

Au S. C., J DERMATOLO IN PRESS

[3] Methods of Outcomes Measurement in Nail Psoriasis [J].

Augustin, M. ;

Ogilvie, A. .

DERMATOLOGY, 2010, 221 :23-28

[4] Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis? [J].

Aydin, Sibel Zehra ;

Ash, Zoe ;

Del Galdo, Francesco ;

Marzo-Ortega, Helena ;

Wakefield, Richard J. ;

Emery, Paul ;

McGonagle, Dennis .

DERMATOLOGY, 2011, 222 (04) :311-313

[5] Moderate to severe plaque psoriasis with scalp involvement: A randomized, double-blind, placebo-controlled study of etanercept [J].

Bagel, Jerry ;

Lynde, Charles ;

Tyring, Stephen ;

Kricorian, Gregory ;

Shi, Yifei ;

Klekotka, Paul .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (01) :86-92

[6] A nail psoriasis severity index [J].

Baran, RL .

BRITISH JOURNAL OF DERMATOLOGY, 2004, 150 (03) :568-569

[7] Remission and time of resolution of nail psoriasis during infliximab therapy [J].

Bianchi, L ;

Bergamin, A ;

de Felice, C ;

Capriotti, E ;

Chimenti, S .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2005, 52 (04) :736-737

[8] Treatment of psoriatic nails with topical cyclosporin:: A prospective, randomized placebo-controlled study [J].

Cannavò, SP ;

Guarneri, F ;

Vaccaro, M ;

Borgia, F ;

Guarneri, B .

DERMATOLOGY, 2003, 206 (02) :153-156

[9] Treatment of severe scalp psoriasis: From the Medical Board of the National Psoriasis Foundation [J].

Chan, C. Stanley ;

Van Voorhees, Abby S. ;

Lebwohl, Mark G. ;

Korman, Neil J. ;

Young, Melodic ;

Bebo, Bruce F., Jr. ;

Kalb, Robert E. ;

Hsu, Sylvia .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (06) :962-971

[10]

COURTOIS M, 1994, SKIN PHARMACOL, V7, P84

← 1 2 3 4 5 6 7 →