Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance

被引：28
|
作者：
Wang, SM
Ryder, H
Pretswell, I
Depledge, P
Milton, J
Hancox, TC
Dale, I
Dangerfield, W
Charlton, P
Faint, R
Dodd, R
Hassan, S
机构：
[1] Xenova Ltd, Dept Med Chem, Slough SL1 4NL, Berks, England
[2] Xenova Ltd, Dept Pharmacol, Slough SL1 4NL, Berks, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期
关键词：
D O I：
10.1016/S0960-894X(01)00804-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：571 / 574
页数：4
相关论文
共 50 条
  • [21] Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors
    Ni, Kai
    Yang, Lei
    Wan, Chuanxing
    Xia, Yuanzheng
    Kong, Lingyi
    NATURAL PRODUCT RESEARCH, 2014, 28 (23) : 2195 - 2198
  • [22] The multidrug resistance protein 1 (Mrp1) - A modulator of vascular function and atherogenesis
    Mueller, CF
    Widder, J
    Czech, T
    Wassmann, S
    Harrison, DG
    Nickenig, G
    CIRCULATION, 2005, 112 (17) : U264 - U264
  • [23] Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1
    Lihua Zhao
    Yanhui Sun
    Xiaoqing Li
    Xianqing Jin
    Youhua Xu
    Zhenhua Guo
    Rui Liang
    Xionghui Ding
    Tingfu Chen
    Siqi Wang
    Medical Oncology, 2011, 28 : 1188 - 1195
  • [24] Identification and characterization of human multidrug resistance protein 1 (MRP1) mutations
    Conrad, S
    Kauffmann, HM
    Ito, K
    Leslie, EM
    Deeley, RG
    Cole, SPC
    Schrenk, D
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2002, 365 : R161 - R161
  • [25] Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)
    Lespine, A
    Dupuy, J
    Orlowski, S
    Nagy, T
    Glavinas, H
    Krajcsi, P
    Alvinerie, M
    CHEMICO-BIOLOGICAL INTERACTIONS, 2006, 159 (03) : 169 - 179
  • [26] Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Dirkje S Postma
    Pieter S Hiemstra
    Lisette IZ Kunz
    Mateusz Siedlinski
    Henriette A Smit
    Judith M Vonk
    Bea Rutgers
    Wim Timens
    H Marike Boezen
    Respiratory Research, 11
  • [27] Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Budulac, Simona E.
    Postma, Dirkje S.
    Hiemstra, Pieter S.
    Kunz, Lisette I. Z.
    Siedlinski, Mateusz
    Smit, Henriette A.
    Vonk, Judith M.
    Rutgers, Bea
    Timens, Wim
    Boezen, H. Marike
    RESPIRATORY RESEARCH, 2010, 11
  • [28] Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
    Bakos, É
    Evers, R
    Sinkó, E
    Váradi, A
    Borst, P
    Sarkadi, B
    MOLECULAR PHARMACOLOGY, 2000, 57 (04) : 760 - 768
  • [29] The multidrug resistance protein 1 (MRP1) modulates vascular function and atherogenesis
    Mueller, C.
    Widder, J.
    Czech, T.
    Chen, C. H.
    Harrison, D. G.
    Nickenig, G.
    EUROPEAN HEART JOURNAL, 2005, 26 : 263 - 263
  • [30] Multidrug resistance strength of the novel multidrug resistance gene HA117: compared with MRP1
    Zhao, Lihua
    Sun, Yanhui
    Li, Xiaoqing
    Jin, Xianqing
    Xu, Youhua
    Guo, Zhenhua
    Liang, Rui
    Ding, Xionghui
    Chen, Tingfu
    Wang, Siqi
    MEDICAL ONCOLOGY, 2011, 28 (04) : 1188 - 1195
12345