Early events regulating immunity and pathogenesis during Listeria monocytogenes infection

被引：46

作者：

Williams, Matthew A. ^{[3
]}

Schmidt, Rebecca L. ^{[1
]}

Lenz, Laurel L. ^{[1
,2
]}

机构：

[1] Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA

[2] Univ Colorado, Sch Med, Integrated Dept Immunol, Aurora, CO 80045 USA

[3] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 10期

关键词：

CD8-ALPHA(+) DENDRITIC CELLS; CD8(+) T-CELLS; NATURAL-KILLER-CELLS; IN-VIVO DEPLETION; CROSS-PRESENTATION; HOST-DEFENSE; IFN-GAMMA; INFLAMMASOME ACTIVATION; MACROPHAGE ACTIVATION; CASPASE-1; ACTIVATION;

D O I：

10.1016/j.it.2012.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Listeria monocytogenes (Lm) is both a life-threatening pathogen of humans and a model organism that is widely used to dissect the mechanisms of innate and adaptive immune resistance to infection. Specific aspects of the immune response to systemic Lm infection can be protective, neutral, or in some cases deleterious. In this review, we seek to provide an overview of the early events during Lm infection that dictate or regulate host innate and adaptive immune responses. We highlight several recent developments that add to our understanding of the complex interplay between inflammatory responses, host susceptibility to infection, and the development of protective immunity.

引用

页码：488 / 495

页数：8

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