Drug discovery strategies to outer membrane targets in Gram-negative pathogens

被引：19

作者：

Brown, Dean G. ^{[1
]}

机构：

[1] AstraZeneca Neurosci, Innovat Med & Early Dev Unit, 141 Portland St,10th Floor, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 24期

关键词：

Antibacterial; Gram-negative; Outer membrane; Lipid A; Lipopolysaccharide; SPHEROPLAST-FORMING ACTIVITY; ESCHERICHIA-COLI; SIGNAL PEPTIDASE; STRUCTURAL BASIS; POLYMYXIN-B; BACTERIAL LIPOPOLYSACCHARIDES; NATURAL-PRODUCTS; MOLECULAR-BASIS; ANTIBIOTICS; LIPOPROTEIN;

D O I：

10.1016/j.bmc.2016.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review will cover selected recent examples of drug discovery strategies which target the outer membrane (OM) of Gram-negative bacteria either by disruption of outer membrane function or by inhibition of essential gene products necessary for outer membrane assembly. Significant advances in pathway elucidation, structural biology and molecular inhibitor designs have created new opportunities for drug discovery within this target-class space. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：6320 / 6331

页数：12

共 91 条

[11] DISTRIBUTION OF MUREIN-LIPOPROTEIN BETWEEN CYTOPLASMIC AND OUTER MEMBRANE OF ESCHERICHIA-COLI [J].

BOSCH, V ;

BRAUN, V .

FEBS LETTERS, 1973, 34 (02) :307-310

[12]

Brown D. G., 2014, INT C ANT AG CHEM IC

[13] Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens [J].

Brown, Dean G. ;

May-Dracka, Tricia L. ;

Gagnon, Moriah M. ;

Tommasi, Ruben .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (23) :10144-10161

[14] New natural products as new leads for antibacterial drug discovery [J].

Brown, Dean G. ;

Lister, Troy ;

May-Dracka, Tricia L. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (02) :413-418

[15] Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections [J].

Brown, Matthew F. ;

Reilly, Usa ;

Abramite, Joseph A. ;

Arcari, Joel T. ;

Oliver, Robert ;

Barham, Rose A. ;

Che, Ye ;

Chen, Jinshan Michael ;

Collantes, Elizabeth M. ;

Chung, Seung Won ;

Desbonnet, Charlene ;

Doty, Jonathan ;

Doroski, Matthew ;

Engtrakul, Juntyma J. ;

Harris, Thomas M. ;

Huband, Michael ;

Knafels, John D. ;

Leach, Karen L. ;

Liu, Shenping ;

Marfat, Anthony ;

Marra, Andrea ;

McElroy, Eric ;

Melnick, Michael ;

Menard, Carol A. ;

Montgomery, Justin I. ;

Mullins, Lisa ;

Noe, Mark. C. ;

O'Donnell, John ;

Penzien, Joseph ;

Plummer, Mark S. ;

Price, Loren M. ;

Shanmugasundaram, Veerabahu ;

Thoma, Christy ;

Uccello, Daniel P. ;

Warmus, Joseph S. ;

Wishka, Donn G. .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (02) :914-923

[16] Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090 [J].

Cole, Kathryn E. ;

Gattis, Samuel G. ;

Angell, Heather D. ;

Fierke, Carol A. ;

Christianson, David W. .

BIOCHEMISTRY, 2011, 50 (02) :258-265

[17] Myxovirescin analogues via macrocyclic ring-closing metathesis [J].

Content, S ;

Dutton, CJ ;

Roberts, L .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (03) :321-325

[18]

DEV IK, 1985, J BIOL CHEM, V260, P5891

[19] Structural basis for outer membrane lipopolysaccharide insertion [J].

Dong, Haohao ;

Xiang, Quanju ;

Gu, Yinghong ;

Wang, Zhongshan ;

Paterson, Neil G. ;

Stansfeld, Phillip J. ;

He, Chuan ;

Zhang, Yizheng ;

Wang, Wenjian ;

Dong, Changjiang .

NATURE, 2014, 511 (7507) :52-U569

[20]

Efren E., 2012, PLOS BIOL, V10

← 1 2 3 4 5 6 7 8 9 10 →